purpose: to determine the maximum safe dose for intravitreal injection of anti-ctgf (ivac) in rat eyes in order to decrease gene and protein expression of connective tissue growth factor (ctgf) for the treatment of ocular fibrotic disorders. methods: forty-five lister hooded pigmented rats were divided into one of the five groups of 9 rats; 4 out of these 5 groups received different doses of iv...

purpose: to compare the efficacy of intravitreal clindamycin and dexamethasone with classic treatment for ocular toxoplasmosis. methods: in this prospective, randomized single-masked clinical trial a total of 68 patients with active ocular toxoplasmosis were assigned randomly to 2 treatment groups: 34 in the intravitreal clindamycin plus dexamethasone (ivcd) group and 34 in the classic treatmen...

purpose: to evaluate the effect of intravitreal triamcinolone acetonide (ivt) reinjection on clinical and optical coherence tomographic (oct) features in refractory diabetic macular edema (dme). methods: in an interventional case series, all ivt-treated patients enrolled in a previous clinical trial (45 subjects), were recalled for performing a new ophthalmologic examination and oct. suitable e...

purpose: to evaluate the effect of intravitreal triamcinolone acetonide (ivt) on clinical, angiographic, and optical coherence tomographic parameters in refractory diabetic macular edema (dme). methods: in a double-masked placebo-controlled randomized clinical trial, 88 eyes of 61 patients with dme refractory to previous laser therapy or not suitable for such treatment were included in the stud...

To report a case of a presumed pyogenic granuloma at the site of multiple intravitreal anti-Vascular Endothelial Growth Factor (VEGF) injections. Intravitreal anti-VEGF injections can be complicated by a localized reaction of the conjunctiva.

PURPOSE To report a case of Coats' disease managed with the dexamethasone intravitreal implant Ozurdex(®) (Allergan, Inc., Irvine, Calif., USA) combined with retinal photocoagulation. METHODS A 46-year-old female with 20/200 visual acuity was diagnosed with Coats' disease with secondary retinal vasoproliferative tumor. An initial approach was performed with an intravitreal injection of the su...

AIM To evaluate the efficacy of intravitreal dexamethasone co-administered with intravitreal antibiotics along with vitrectomy in the management of exogenous bacterial endophthalmitis. METHODS In a prospective randomised clinical trial, 63 patients (63 eyes) with suspected bacterial endophthalmitis (postoperative and post-traumatic) were treated with vitrectomy and intravitreal antibiotics an...