It has been suggested that oxidative stress contributes to impaired left ventricular (LV) contractility in the setting of heart failure (HF). To test this hypothesis, we studied the effect of an antioxidant on contractility at rest and in response to dobutamine in 10 HF patients. We hypothesized that vitamin C would augment contractility in HF and that this effect would be of a greater magnitud...

BACKGROUND The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries. METHODS In this retrospective before-after clinical study, we compared the outcome and clinical course of consecutive septic patients treated with intravenous vitamin C, hydrocortisone, and thiamine during a 7-month period (treatment group) wit...

vitamin e (alpha-tocopherol) is a potent and natural antioxidant. vitamin e is concentrated from soybean oil. the committee on fetus and newborn of the academy of the american of pediatrics endorsed 1 to 2 mg/dl as the normal range of serum tocopherol level. human infants are born with low stores of vitamin e, thus they require an adequate intake of vitamin e soon after birth. the optimum intra...

The recent article by J. Cha et al. provided for highly interesting reading [1].Vitamin C may attenuate tumor growth in a number of other systemic malignancies. Vitamin C has a negative impact on tumor growth in breast cancers. Similarly it mitigates tumor metastasis. It mediates this effect in part by attenuating IL-6 levels [2]. Similar effect is seen on VEGF levels. Interestingly, intravenou...

In order to study the interaction of glutathione, vitamin C and vitamin E under hyperoxia (95 % oxygen) and hyperbaric oxygen (2.5 atmospheric pressure), 20 days old male Guinea pigs were fed with basal vitamin C free diet, while receiving a vitamin C supplement of either high concentration (50 mg/day) or low concentration (1 mg/day) for two weeks. Animals were than exposed to hyperoxia and hyp...

AIM The aim of the study was to evaluate under praxis conditions the safety and efficacy of intravenous (i.v.) vitamin C administration in the first postoperative year of women with breast cancer. PATIENTS AND METHODS Epidemiological multicentre cohort study, including 15 gynaecologists and general practitioners representatively distributed in Germany. Data from 125 breast cancer patients in ...

Background: Paraquat is nonselective bipyridyl herbicide that induces hepatotoxicity through oxidative stress. Vitamin C and chitosan have antioxidant as well as radical scavenger properties and show protective effects against reactive oxygen species (ROS). In the present study, hepatoprotective effects of chitosan and vitamin C were evaluated in common carp exposed to paraquat. Methods: Whi...

SummaryBackground Interleukin 6 is an important biomarker for distinguishing high-risk and low-risk patients, a constituent of the Nutrition Risk in Critically III (NUTRIC) Score. Studies have indicated beneficial effects vitamin C on lowering IL-6 levels reducing cytokine storm. However, there still controversy about exact effect, appropriate route, dose usage. This meta-anal...