150 words) Study Objective To compare intranasal fentanyl (INF) with intravenous morphine (IVM) for prehospital analgesia. Methods Randomized, controlled, open-label trial. Consecutive adult patients (n=258) requiring analgesia (Verbal Rating Score (VRS) >2/10 non-cardiac or >5/10 cardiac) were recruited. Patients received INF 180mcg +/2 doses of 60 mcg at ≥ 5 minute intervals, or IVM 2.5-5mg +...

BACKGROUND Cerebral coenurosis is a disease of the central nervous system in sheep and goats, and is usually fatal unless surgical relief is provided. Information regarding neuroanaesthesia in veterinary medicine in goats is scant. CASE PRESENTATION We describe anaesthetic management of an intact female goat (2 years; 16 kg) presented for craniectomy. The goat was sedated with xylazine (0.05 ...

Propofol is one of the most popular intravenous anaesthetic used for induction and maintenance anaesthesia sedation in outside operating room. Its role valuable especially day care surgeries with larngeal mask airways. Because high incidence pain on propofol injection (POPI) numerous interventions have been tested to prevent this including use different drugs physical measures as well combinati...

BACKGROUND Anxiety control remains an important concern in dental practice. We evaluated the incidence, nature, and sequelae of complications during and after minor oral surgeries performed under intravenous midazolam and fentanyl sedation using the titration technique. METHODS The medical records of patients who had undergone minor oral surgeries under moderate intravenous midazolam and fent...

PURPOSE To investigate whether the nasal route for fentanyl administration in patient-controlled analgesia (PCA) provides as effective postoperative analgesia as intravenous PCA. METHODS Patient-controlled intranasal or intravenous analgesia with fentanyl was investigated in 48 patients (ASA I-III) on the day of surgery (orthopedic, abdominal or thyroid) in a prospective, randomized, double-b...

BACKGROUND A pulse oximeter is a standard device for perioperative monitoring. It is well known that the early detection of tissue hypoxia is of great importance. It has been made easier due to a new generation pulse oximetry device from Masimo. This enables measurements of the peripheral perfusion index (PI) in real time. It has been found that volatile anaesthetics such as sevoflurane and des...

Fentanyl-induced cough is not an uncommon condition during the induction of general anesthesia. A preliminary randomized controlled study was designed to observe the effects of different priming doses of propofol on fentanyl-induced cough during anesthesia induction. A total of 120 patients were randomized into 4 groups (n = 30) to receive the intravenous injection of intralipid (group I), prop...

P-glycoprotein (PGP) is a polymorphic transporter encoded by the ABCB1 gene that contributes to the access of xenobiotics into the brain. There is no report on associations between genetic polymorphisms in ABCB1 and the clinical effects of fentanyl, although fentanyl may be a substrate of PGP. One hundred and twenty-six (126) unrelated Korean patients under spinal anesthesia with intravenous fe...

PURPOSE Fracture of femur is a painful bone injury, worsened by any movement. This prospective study was performed to compare the analgesic effects of femoral nerve block (FNB) with intravenous (IV) fentanyl prior to positioning patients with fractured femur for spinal block. PATIENTS AND METHODS Sixty-four ASA I-III patients aged 18-80 years undergoing surgery for femur fracture were randomi...