OBJECTIVES To evaluate the influence of the ORM1 variants in codon 118 on the intra-operative remifentanil consumption under general anesthesia. Methods: A prospective gene association study, performed at the Jordan University Jordan, Amman, Jordan from September 2013 to August 2014. It includes patients who underwent septoplasty surgery under general anesthesia. All patients received standard ...

Current concepts of the molecular and cellular mechanisms that underlie general anesthetic actions are incomplete. This is both surprising, given that leading scientists have approached this problem for more than a century, and unfortunate since this lack of knowledge limits our ability to employ these important drugs with optimal safety and efficacy. Considerable evidence now implicates agent-...

a bstract background: shivering is a common complication of general and epidural anesthesia. warming methods and many drugs are used for control of shivering in the recovery room. the present study is a randomized clinical trial aimed to investigate the effects of two interventions in comparison with pethidine which is the routine treatment on shivering in patients undergoing abdominal surgery ...

Attempts were made to control prolonged seizures with rapid intravenous administration of either diazepam or methohexitone in relatively small doses under electroencephalographic (EEG) monitoring. The clinical and EEG features are discussed in relation to 65 episodes which occurred in 51 infants and children. Both clinical and EEG effects may become apparent in half a minute when the drug is ad...

A severe case of flecainide-induced incessant ventricular arrhythmias is presented. These arrhythmias were resistant to various intravenous antiarrhythmic drugs and to cardiac pacing. Intravenous amiodarone administered over a short period and in a high dose strikingly abolished all ventricular arrhythmias.

Acute renal failure is one of the side effects while using intravenous immunoglobulins. This complication is also observed with iodinated contrast media. Herein, we describe a patient with acute renal failure who received intravenous immunoglobulins and iodinated contrast media concomitantly. Both drugs are responsible for osmotic nephrosis. The same effect on renal cells may explain a synergis...

Intravenous administration of fluids, drugs, and nutrition is very common in hospitals. Although insertion of peripheral and central cannulae and subsequent intravenous therapy are usually well tolerated, complications that prolong hospitalisation, and in some cases cause death, can arise on occasions. Additionally, many cannulae are inserted unnecessarily. This article seeks to review this are...

BACKGROUND Pathological laughter can be a sign of epilepsy, psychiatric illness, effect of toxins or psychotropic drugs or of structural brain disease. METHOD Case Studies. RESULT Two patients developed inappropriate uncontrollable laughter following intravenous sodium valproate for treatment of epilepsy. CONCLUSION Pathological laughter can be a side effect of intravenous sodium valproate.

background   lipoprotein lipase activity can be increased by clofibrate. clofibrate is used to reduce serum triglyceride level in adults. the aim of this study was to determine the effect of clofibrate on serum triglyceride and cholesterol level after administration of intravenous lipid in very low birth weight neonates. method in a randomized double blind placebo – controlled study, 60 very lo...