High rates of tuberculosis (TB) and HIV are believed to exist in Russian prisons. Prisoners with TB were studied in order to identify the following: 1) prevalence of HIV, and risk factors for HIV and other blood-borne virus infections; and 2) clinical and social factors that might compromise TB treatment effectiveness and/or patient adherence and, hence, encourage treatment failure. A 1-yr cros...

Nonclinical assessment of drug abuse and dependence is the subject of several recent regulatory guidelines, which are generally aligned on the methods to be employed. The most direct approach to assessing reinforcing properties of a drug is the self-administration procedure whereby animals can initiate intravenous injections of the test substance, something they readily do with prototypic drugs...

background: hepatitis c (hcv) is increasing worldwide including iran. hcv is more prevalent among intravenous drug abusers (idu), especially if imprisoned, mostly due to needle sharing. we determined the rate of hcv seropositivity among idu prisoners and compared it with those of non prisoners. materials and methods: a cross-sectional survey was done on consenting idu inhabiting two prisons and...

Nonclinical assessment of drug abuse and dependence is the subject of several recent regulatory guidelines, which are generally aligned on the methods to be employed. The most direct approach to assessing reinforcing properties of a drug is the self-administration procedure whereby animals can initiate intravenous injections of the test substance, something they readily do with prototypic drugs...

Animal models have been developed to study the reinforcing effects of drugs, including the intravenous self-administration (IVSA) paradigm. The advantages of using an IVSA paradigm to study the reinforcing properties of drugs of abuse such as cocaine include the fact that the drug is self-administered instead of experimenter-administered, the schedule of reinforcement can be altered, and accura...

A 56-year-old man has been admitted on several prior occasions for left groin abcesses related to injection drug use. Comorbid disorders include diabetes and tobacco abuse. Recent test results for HIV and TB (PPD test) were negative. On past admissions related to intravenous abuse of heroin and cocaine, the patient was treated with antibiotics and incision with drainage. A CXR and subsequent CT...

BACKGROUND AND OBJECTIVE Abuse of opioid analgesics has become a public health issue. Some opioid abusers use intravenous administration to increase the magnitude of positive reinforcing effects. Intravenous co-administration of oxycodone with naloxone, an opioid antagonist, may reduce these rewarding effects and discourage abuse. A 2:1 oxycodone:naloxone (OXN) tablet formulation has been studi...

INTRODUCTION Persons serving a prison sentence are identified as a population exposed to a higher risk of HIV/STIs due to a high incidence of risk behaviour, especially intravenous drug misuse. To show results of research on prevalence of HIV/STIs in relation to spread of risk behaviour and other risk factors. SUBJECTS AND METHODS Cross-sectional study on a sample of 620 respondents in 10 pri...

Purpose To describe an unusual case of intravenous drug abuse associated endogenous endophthalmitis presenting with an iris abscess. Observations A 30-year old female with history of intravenous drug use presented with a two-week history of redness and blurry vision in the right eye. An initial diagnosis of anterior uveitis was made. However, she worsened on topical steroids and mydriatics. S...