Immune privilege of the eye protects against sight-threatening inflammatory events, but can also permit outgrowth of otherwise nonlethal immunogenic tumors. Nonetheless, ocular tumor growth can be controlled by cellular immune responses. However, this will normally result in phthisis of the eye, in case tumor rejection is mediated by a delayed-type hypersensitivity response orchestrated by CD4(...

PURPOSE To study the differential expression of microRNA (miRNA) profiles between intraocular medulloepithelioma (ME) and normal control tissue (CT). MATERIAL AND METHODS Total RNA was extracted from formalin fixed paraffin embedded (FFPE) intraocular ME (n=7) and from age matched ciliary body controls (n=8). The clinical history and phenotype was recorded. MiRNA profiles were determined usin...

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PURPOSE To establish human retinoblastoma (RB) animal models that allow sensitive, noninvasive and continuous monitoring of tumor growth and metastasis in vivo. METHODS The human RB tumor cell lines HXO-Rb44 and Y79 were engineered to express a fusion reporter gene allowing for bioluminescence and fluorescence imaging. Intraocular and metastatic tumors were induced in immunodeficient nude mic...

OBJECTIVE To report the clinical characteristics of solitary idiopathic choroiditis and the features that differentiate it from tumors and other inflammatory lesions. DESIGN Retrospective medical record review. PATIENTS Sixty consecutive patients with solitary idiopathic choroiditis. MAIN OUTCOME MEASURES Clinical features, natural course, and follow-up. RESULTS The mean and median ages...

Relatively few malignant neoplasms have been described in amphibia. The one that has been studied most extensively is the Luck6 renal adenocarcinoma of the frog, Rana pipiens. This malignant tumor occurs in from two to four per cent of frogs of this species, collected in the Lake Champlain region of northern Vermont and adjoining areas of Quebec. In a series of papers Luck6 described its histop...

Relatively few malignant neoplasms have been described in amphibia. The one that has been studied most extensively is the Luck6 renal adenocarcinoma of the frog, Rana pipiens. This malignant tumor occurs in from two to four per cent of frogs of this species, collected in the Lake Champlain region of northern Vermont and adjoining areas of Quebec. In a series of papers Luck6 described its histop...

Optical coherence tomography (OCT) plays an instrumental role in the diagnosis and follow-up of several retinal and choroidal diseases such as macular degeneration, vascular occlusion, and inflammation. Recently, OCT studies of intraocular tumors evaluated the intrinsic optical characteristics of choroidal tumors imaged using enhanced depth imaging OCT (EDI-OCT). Among body structures, the chor...

To compare the number of tumors per eye for mosaic carriers RB1 pathogenic variants with full germline and conversion from unilateral to bilateral disease. Retrospective cohort study comparing patients retinoblastoma different genetic subtypes: high penetrance (HP), low (LP), mosaicism. Data were analyzed between 1992 2018 at Retinoblastoma Unit, Royal London Hospital, London, United Kingdom. A...