Background Diffusion-Tensor cardiovascular magnetic resonance (DT-CMR) is capable of mapping myocardial fiber orientation [1,2]. It has been demonstrated in myocardial infarction (MI) murine models that DT-CMR can identify the effects of stem cell therapy on myocardial fiber orientation [3]. However, it remains to be seen if this recent work is translatable to large animal and clinical studies....

Intramyocardial calcification is a very rare condition. We report a case of a 72-year-old man with apical hypertrophic cardiomyopathy, who was initially suspected of having a thrombus in the left ventricular apex on echocardiography, but was finally diagnosed as having apical intramyocardial calcification on multidetector computed tomography. The mechanism of developing intramyocardial calcific...

Methods We tested human ferritin heavy chain (hFTH) tagged with both myc and green fluorescence protein (GFP) as a reporter gene for in vivo tracking of stem cells by cardiac MR. Rat mesenchymal stem cells (rMSCs) were transduced with lentiviurs to overexpress hFTH. Myocardia infarction was induced by cryoinjury in rats, and the animals were immediately subjected to intramyocardial injection of...

The first clinical trials of stem cell (SC) treatment for cardiac disease in humans, using autologous bone marrow cell transplantation in patients with severe chronic heart failure (HF), were reported in 2002 (using the intracoronary injection route) and in 2003 (using the intramyocardial injection route). Since those initial reports, numerous additional clinical SC trials have been conducted i...

PURPOSE To define intramyocardial triglyceride (TG), creatine (Cr), and choline (Cho) in healthy volunteers, and determine the feasibilities, scan durations and agreements between cardiac proton magnetic resonance spectroscopy ([(1)H]-MRS) performed with fewer signal averages versus a reference standard with 128 signal averages. MATERIALS AND METHODS Thirty-one participants underwent [(1)H]-M...