BACKGROUND Early postoperative mobilization is essential for an enhanced recovery, but it can be hindered by orthostatic intolerance, characterized by signs of cerebral hypoperfusion, such as dizziness, nausea, vomiting, and ultimately syncope. Orthostatic intolerance is frequent after major surgical procedures, because of an attenuated cardiovascular response, but the cardiovascular response a...

BACKGROUND AND OBJECTIVES Distress intolerance is a core element of many models of psychopathology and is related to a range of disorders and maladaptive behaviors. However, research on distress intolerance has been hampered by inconsistency in its assessment. Moreover, recent perspectives suggest that distress intolerance varies based on the domain of distress, highlighting the need for a meas...

BACKGROUND Methotrexate (MTX) intolerance is a frequent problem of long-term treatment in juvenile idiopathic arthritis (JIA). Mutations in the methylentetrahydrofolate reductase (MTHFR) gene may increase toxicity of MTX, potentially constituting an initial stimulus for this conditioned response. The objective of this study was to investigate the relationship of common MTHFR gene mutations and ...

Intolerance of uncertainty has been identified as an important variable related to worry and Generalized Anxiety Disorder (GAD) [Dugas, M. J., Gagnon, F., Ladouceur, R., & Freeston, M. H. (1998). Generalized anxiety disorder: a preliminary test of a conceptual model. Behaviour Research and Therapy, 36, 215-226; Ladouceur, R., Dugas, M. J., Freeston, M. H., Rhéaume, J., Blais, F., Boisvert, J.-M...

cognitive restructuring and exposure therapy have been integrated into a highly structured package for the treatment of social phobia termed cognitive-behavioral group therapy (cbgt). the first two sessions of cbgt for social phobia are devoted to training clients in the basic tenets of cognitive therapy. clients learn to identify their own irrational thoughts and to challenge the content of th...

objective: social phobia is considered as one of the most common anxiety disorders. the researchers have been looking for the basic mechanism behind it, since determining these factors can be influential in prevention and treatment. in recent years, some of the most important personality and cognitive correlates of social phobia including neuroticism, fear of negative evaluation, anxiety sensit...