BACKGROUND Insulin-like growth factor-I receptor (IGF-IR) is a tyrosine kinase receptor (RTK) associated with caveolae, invaginations of the plasma membrane that regulate vesicular transport, endocytosis and intracellular signaling. IGF-IR internalization represents a key mechanism of down-modulation of receptors number on plasma membrane. IGF-IR interacts directly with Caveolin-1 (Cav-1), the ...

Internalization is at study in social-behavioural sciences and moral philosophy; lately, the debate was revamped within the rationality approach to the study of cooperation and compliance because internalization is a less costly and more reliable enforcement system than social control. But how does it work? So far, poor attention was paid to mental underpinnings of internalization. This article...

A protein neurotoxin (Bgt 3.1) present as a minor component in the venom of Bungarus multicinctus has been shown previously to block acetylcholine (ACh) sensitivity on chick ciliary ganglion (CG) neurons in cell culture. Alpha-bungarotoxin (Bgt. 2.2) binds to the neurons but does not block ACh sensitivity; the function of the Bgt. 2.2 binding site is unknown. The present studies demonstrate tha...

CXCL8 (interleukin-8) interacts with two receptors, CXCR1 and CXCR2, to activate leukocytes. Upon activation, CXCR2 internalizes very rapidly relative to CXCR1 ( approximately 90% versus approximately 10% after 5 min). The C termini of the receptors have been shown to be necessary for internalization but are not sufficient to explain the distinct kinetics of down-regulation. To determine the st...

Exploring the role of polymer structure for the internalization of biologically relevant cargo, specifically siRNA, is of critical importance to the development of improved delivery reagents. Herein, we report guanidinium-rich protein transduction domain mimics (PTDMs) based on a ring-opening metathesis polymerization scaffold containing tunable hydrophobic moieties that promote siRNA internali...

1. The moderate relationship between internalization of Sabbath keeping and well-being will replicate in a new sample of Seventh-day Adventist young adults. 2. Need satisfaction, reported on a survey and coded from Sabbath keeping narratives (as in Philippe, Koestner, Beaulieu-Pelletier, & Lecours, 2011), will be positively related to well-being and internalization of Sabbath keeping. 3. For li...

Studies on cultured cells have shown that agonists induce several types of G protein-coupled receptors to undergo internalization. We have investigated this phenomenon in rat striatum, using substance P (SP)-induced internalization of the SP receptor (SPR) as our model system. Within 1 min of a unilateral striatal injection of SP in the anesthetized rat, nearly 60% of the SPR-immunoreactive neu...

This study examined the associations among self-concept clarity, thin-ideal internalization, appearance-related social comparison tendencies, and body dissatisfaction. Female university students (N=278) completed self-report measures of these constructs. Structural equation modeling revealed several key findings: (a) thin-ideal internalization mediated the link between appearance-related social...

Flowing leukocytes tether to and roll on P-selectin, a receptor on endothelial cells that is rapidly internalized in clathrin-coated pits. We asked whether the association of P-selectin with clathrin-coated pits contributes to its adhesive function. Under flow, rolling neutrophils accumulated efficiently on CHO cells expressing wild-type P-selectin or a P-selectin construct with a substitution ...