Within the framework of radiation protection or internal radiotherapy, one of the major stakes is to determine in a most realistic possible way the dose received by every patient. In this purpose, a tool called OEDIPE, French acronym for “tool for personalized internal dose assessment”, was developed at IRSN associating numerical voxelized phantoms, created with anatomical images, and Monte Car...

Background: Reliable estimation of radiation-absorbed dose is necessary to evaluate the benefits and the risks of radiopharmaceuticals used for diagnostic or therapeutic purposes in nuclear medicine. Materiel and Methods: This study included 47 patients treated with iodine-131 for Graves’ disease. A comparative study between Geant4 Monte Carlo simulation and MIRD formalism was carried out to ev...

Alternatives for developing chronic exposure limits for noncancer effects of trichloroethylene (TCE) were evaluated. These alternatives were organized within a framework for dose-response assessment--exposure:dosimetry (pharmacokinetics):mode of action (pharmacodynamics): response. This framework provides a consistent structure within which to make scientific judgments about available informati...

Dose reconstruction is a comprehensive analysis of the exposure received by individuals in the vicinity of facilities that release contaminants to the environment (i.e., real doses to real people).Performing dose reconstruction analyses which are extremely important elements for improving efficiency in radiological emergencies and accidents have been studied in this paper. For dose reconstructi...

A 65 year old male with metastatic colorectal cancer (mCRC) in the liver was referred for selective internal radionuclide therapy (SIRT) following a history of extensive systemic chemotherapy. 90Y PET imaging was performed immediately after treatment and used to confirm lesion targeting and measure individual lesion absorbed doses. Lesion dosimetry was highly predictive of eventual response in ...

Bystander and low-dose-rate effects influence the dose-response relationship in a manner not predicted by current dosimetric methodologies. Radiation-induced bystander effects refer to biologic responses in cells that are not traversed by an ionizing radiation track and, thus, not subject to direct energy deposition; that is, the responses occur in nonirradiated cells. Low-dose-rate hypersensit...