GVHD: Graft-Versus-Host Disease; HSCT: Hematopoietic Stem Cell Transplantation; CsA: Cyclosporine; MHC: Major Histocompatibility Complex; CLIP: Class II Invariant Chain Peptide; IL-2: Interleukin-2; IL-4: Interleukin-4; IL-5: Interleukin-5; IL-10: Interleukin-10; IFN-γ:Interferon-γ; TNF-α: Tumor Necrosis Factor-α; TGF-β: Transforming Growth Factor-β; TCR: T-Cell Receptor; SEB: Staphylococcal En...

Rheumatoid arthritis (RA) is complex autoimmune system disease and significant impact on the health of population in our world. Numerous studies confirmed that genetic factors play a crucial role pathogenesis RA. Interleukin-6 (IL-6) common pro-inflammatory cytokine with various functions different pathophysiologic systems, especially development The (IL-6)is affected by common, functionally im...

Successful embryo implantation and appropriate trophoblast invasion is associated with an adequate communication interaction between peripheral blood mononuclear cells (PBMC) the human embryo. Human chorionic gonadotropin (hCG) one of earliest embryonic signals that affect PBMC cytokine secretion. Nowadays, intrauterine administration hCG-activated autologous a widely used treatment for improve...

In the long-term period after kidney transplantation, a certain level of tissue inflammation and therefore production proinflammatory cytokines, including TNF-α, IL-1β, IL-18 IL-2 can be found. The aim our study was to determine concentrations IL-18, its soluble receptor (IL-2R) in renal transplant patients, regarding length postoperative period. involved 65 transplanted at least 12 months prio...

Objective: To explore the clinical therapeutic effect of Hongteng decoction combined with levofloxacin on chronic pelvic inflammatory disease (CPID) patients and its expression factors. Methods: 72 CPID who were diagnosed treated in Fourth Hospital Shijiazhuang City from January 2020 to December selected randomly divided into observation group (n = 36) control 36). The was retention enema basis...

Abbreviations: RA: Rheumatoid Arthritis; CIA: Collagen-Induced Arthritis; IL-1β: Interleukin-1β; IL-6: Interleukin-6; IL-17A: Interleukin17A; IFN-γ: Interferon-γ; TNF-α: Tumor; Necrosis Factor-α; GM-CSF: Granulocyte-Macrophage Colony-Stimulating Factor; IL-8: Interleukin-8; MTX: Methotrexate; CSA: Cyclosporine; AZA: Azathioprine; LEF: Leflunomide; CFA: Complete Freund’s Adjuvant; ELISA: Enzyme ...

henoch–schönlein purpura (hsp), a common allergic hemorrhagic disease, occurs frequently in children affecting kidney, joint and skin. while interleukin-8 (il-8) plays an important role in inflammation, the association between il-8 gene +781 c/t polymorphism and hsp remains unclear. interleukin-8, an important chemokine related to the initiation and amplification of acute inflammatory responses...

Introduction: Klotho and dipeptidyl peptidase-4 (DPP4) are two proteins that modulate inflammatory pathways. We investigated the association between circulating klotho and DPP4 activity and their relationship with inflammatory cytokines, miR-29a, and miR-195 in Alzheimer disease (AD). Methods: This study was conducted on 16 AD patients and 16 healthy age-matched controls. Plasma levels of tumo...

recent studies have established that sex hormones directly or indirectly affect t and b cells and macrophages by manipulating the production of cytokines. in this study the possibility of the effect of 5a-dht on macrophage (mφ) nitric oxide (no) release via interleukin-l, 6 (ll-1β, il-6) or tumor necrosis factor-a (tnfα) was investigated. the endogenous cytokines il-1β, il-6 and tnf-α were neut...

background: interleukin-27 is a heterodimeric cytokine belonging to il-12 and il-23 families, secreted  by antigen presenting cells( apcs ) .the il-27 is composed of 2 subunits: epstein-barr virus induced gene 3 (ebi3) and p28. il-27 is an anti-inflammatory cytokine which has an inhibitory effect on th17 population and suppress the il-17 expression. it is suggested that il-27 could be a potent ...