Background: Rheusmatoid arthritis (RA) is a chronic systemic disease characterized by articular involvement and extra-articular manifestation. A cytokine with immunomodulatory properties, interleukin-21 (IL-21) influences both the innate acquired immunity. The aim of this work was to detect IL-21 polymorphism (rs2221903) in cases RA determine its role pathogenesis activity disease.Methods: This...
