Insulin resistance, the hallmark of non-insulin dependent diabetes mellitus, is characterized by the failure of tissues to take up and store glucose in response to insulin. Two recent studies shed new light on the importance of insulin signalling in the liver and how this may become defective in diabetes.

An epidemiological study was carried out to compare the prevalence of facial flushing in non-diabetics, patients with insulin dependent diabetes, and patients with non-insulin dependent diabetes in response to 40 ml sherry taken 12 hours after 250 mg chlorpropamide or placebo, administered double blind in randomised order. A flush after chlorpropamide but not placebo was reported by 6.2% of non...

Insulin concentrations in humans continuously change and typically increase only when glucose also increases such as with eating. In this setting, it is not known whether the severity of hepatic and extrahepatic insulin resistance is comparable and whether the ability of glucose to regulate its own uptake and release is defective in non-insulin-dependent diabetes mellitus (NIDDM). To address th...

OBJECTIVE Previous studies have shown that endothelial dysfunction, an early sign of atherosclerosis, occurs in animal models of diabetes mellitus and in resistance vessels of patients with insulin-dependent diabetes. In the present study we examined whether young patients with insulin-dependent diabetes without microalbuminuria present abnormal endothelial function of large peripheral arteries...

conclusions the lh is a common problem in insulin-treated jordanian patients with t2dm. more efforts are needed to educate patients and health workers on simple interventions such as using shorter needles and frequent rotation of the insulin injection sites to avoid lh and improve glycemic control. results the overall prevalence of lh was 37.3% (27.4% grade 1, 9.7% grade 2, and 0.2% grade 3). t...

Noninsulin-dependent diabetes or adult-onset which is currently known as T2DM occurs a result of peripheral resistance to the hormone insulin insufficient amount produced by pancreas (relative rather than absolute deficiency), it represents 90-95% all [1].

Presented at the International Society for Pharmacoeconomics and Outcomes Research Milan, Italy | November 7–11 2015 Conclusions Objective The Role of Education in the Management of Type 1 Diabetes Mellitus in England Courtney Toth,1 William Marsh,1 Gavin Stewart,1 Lisa Yang,1 Harriet Bridges,2 Jeanette Kusel1 1Costello Medical Consulting Ltd, Cambridge, UK; 2Employee at Costello Medical Consul...