AIMS Patients with conditions that are associated with insulin resistance such as obesity, type 2 diabetes mellitus, and polycystic ovary syndrome have an increased risk of thrombosis and a concurrent hyperactive platelet phenotype. Our aim was to determine whether insulin resistance of megakaryocytes/platelets promotes platelet hyperactivation. METHODS AND RESULTS We generated a conditional ...

Too large instance and/or feature number for supervised classification requires higher storage demands and computing time, and also the classification quality may suffer from too huge datasets. In our work we examine the reduction of training instance number in music genre recognition where each instance is mapped to a class described by a corresponding 2-gram estimated from the statistical dis...

AIMS Fourier transform infrared (FT-IR) was used to analyse a selection of Acinetobacter isolates in order to determine if this approach could discriminate readily between the known genomic species of this genus and environmental isolates from activated sludge. METHODS AND RESULTS FT-IR spectroscopy is a rapid whole-organism fingerprinting method, typically taking only 10 s per sample, and ge...

Despite of the huge socio-economic burden, stroke still represents an unmet therapeutic need. Researchers failed to reproduce preclinical efficacy in subsequent clinical development. To bridge this translation failure, the Stroke Therapy Academic Industry Round Table (STAIR) has suggested a rigorous, robust, and detailed preclinical evaluation in at least 2 species and multiple cerebral ischemi...

Inflammation after renal ischemia-reperfusion (IR) injury is a major contributor to renal cell death. We previously demonstrated that several volatile anesthetics protect against renal IR injury and necrosis in rats in vivo. We subsequently showed that volatile anesthetics produced direct anti-inflammatory and anti-necrotic effects in cultured proximal tubule cells in vitro. In this study, we w...

polyaniline and polyamide (nylon 6,6) nanocomposites with silva were prepared by in-situ oxidativepolymerization of aniline monomers in the presence of ag salt nano particles of silver (nps) were symthesieedby controlled reduction of ag+ ions kith sodium borohydride at room temperature. nylon 6,6 wax loaded withag nanoparfieles by erdrapment of ag+ ions into the polymer network, followed by red...

Let (R;m) be a Noetherian local ring and let I be an R-ideal. The associated graded ring of I, G = grI(R), plays a significant role in the study of resolution of singularities. Its relevance lies upon the fact that it represents algebraically the exceptional fiber of the blowup of a variety along a subvariety. A commonly addressed issue is to find numerical conditions that imply lower bounds on...

Gold nanoparticles are one of the most used nanomaterials. They are usually synthesized by the reduction of gold(III) chloride. However, the presence of halide ions in the reaction mixture is not always welcome. In some cases, these ions have detrimental influence on the morphology and structure of resulting nanoparticles. Here, we present a simple and halogen-free procedure to prepare gold nan...

Nowadays, cross-lingual Information Retrieval (IR) is one of the greatest challenges to deal with. Besides, one of the most important issues in IR consists in the corpus vocabulary reduction in order to make possible to use in real situations some methods of IR such as the well-known vector space model. In this work, we have considered a vocabulary reduction process based on the selection of mi...