Sister chromatid exchanges (SCEs) are considered sensitive indicators of genome instability. Detection of SCEs typically requires cells to incorporate bromodeoxyuridine (BrdU) during two rounds of DNA synthesis. Previous studies have suggested that SCEs are induced by DNA replication over BrdU-substituted DNA and that BrdU incorporation alone could be responsible for the high number of SCE even...

Mutations in the DNA mismatch repair (MMR) system lead to an instability of simple repetitive DNA sequences involved in several cancer types. This instability is reflected in a high mutation rate of microsatellites, and recent studies in colon cancer indicate that defects in MMR result in frequent frameshift mutations in mononucleotide repeats located in the coding regions of BAX and transformi...

Abstract. Two entropic dynamical models are considered. The geometric structure of the statistical manifolds underlying these models is studied. It is found that in both cases, the resulting metric manifolds are negatively curved. Moreover, the geodesics on each manifold are described by hyperbolic trajectories. A detailed analysis based on the Jacobi equation for geodesic spread is used to sho...

an important problem in performance evaluations of irrigation systems is the difficulty of the determining share of structural and operational elements and determining improvement solutions. in most studies, the combined impact of structural and operational elements on the performance of irrigation systems is assessed. some researchers try to separate the effects of structural and operational e...

Mutations in the DNA mismatch repair (MMR) system lead to an instability of simple repetitive DNA sequences involved in several cancer types. This instability is reflected in a high mutation rate of microsatellites, and recent studies in colon cancer indicate that defects in MMR result in frequent frameshift mutations in mononucleotide repeats located in the coding regions of BAX and transformi...

This paper tests empirically the Dutch disease macroeconomic dynamics in a set of oil exporting countries. Accordingly, this study was put forth to provide an assessment of the Dutch disease symptoms, by focusing on the link between macroeconomic instability indicators and economic growth. To this end, we assess the risk to real exchange rate, government spending and price stability from the oi...

introduction: assessing quality of life for patients with shoulder instability may be essential because of the negative impacts of the disease on patient’s life. the aim of the present study, therefore,  was  to  assess  the  internal  validity  and  consistency,  test-retest  reliability,  and convergent validity of the persian version of the oxford shoulder instability score (osis). material ...

The present paper explores the relationships between two commodity market indicators and stock market in India using daily time series data of 2 nd January 1991 – 31 st December 2012 comprising 5321 observations in the midst of employing Johansen co integration approach and Granger causality method. During the last two decades, both crude oil price and gold price (except 1997-2001) have been in...

The study of offender trajectories has been a prolific area of criminological research. However, few studies have incorporated the influence of emerging adulthood, a recently identified stage of the life course, on offending trajectories. The present study addressed this shortcoming by introducing the "prolonged adolescent" offender, a low-level offender between the ages of 18 and 25 that has f...