Disruption of the central nervous system (CNS) barriers is one of the major pathophysiological consequences of bacterial meningitis. The increase in the permeability of the CNS barriers caused by the disruption is thought to contribute to the development of adverse neurological outcomes. We have established a method by which the CNS barrier permeability can be demonstrated by the gadolinium-enh...

In organic light-emitting diodes (OLEDs), electrons are injected from the cathode into the π*-band (lowest unoccupied molecular orbital) of an organic semiconductor and holes are injected from the anode into the π-band (highest occupied molecular orbital). If the work function of the cathode is greater than the π*-band or the work function of the anode is less than the π-band, these differences...

Ultraviolet photoelectron spectroscopy has been used to determine the energy level alignment at interfaces of molecular hole-transporting materials and various conductive substrates. Depending on the work function of the substrate, s, a transition between two different energy level alignment regimes has been observed: namely vacuum level alignment and Fermi level pinning. The transition is ass...

purpose: to evaluate the effects of intravitreal and intracameral injection of bevacizumab in patients with neovascular glaucoma (nvg).   methods: this interventional case series was conducted on 40 eyes of 40 patients with neovascular glaucoma. data included the extent of iris (nvi) and angle neovascularization (nva), peripheral anterior synechia (pas), and intraocular pressure (iop). followin...

For the modularized start version of the FAIR project, a scenario was proposed with accumulation of antiprotons in the High Energy Storage Ring (HESR). The accumulation uses pre-cooled antiprotons from the Collector Ring (CR) for longitudinal accumulation by the combination of barrier buckets and stochastic cooling. As a benchmarking of computer simulations and for studies of technical requirem...

Targeted delivery of drugs across endothelial barriers remains a formidable challenge, especially in the case of the brain, where the blood-brain barrier severely limits entry of drugs into the central nervous system. Nanoparticle-mediated transport of peptide/protein-based drugs across endothelial barriers shows great potential as a therapeutic strategy in a wide variety of diseases. Functiona...

In the United States, homeless youth are becoming increasingly entrenched in problem substance use, including high prevalence of alcohol abuse and injection use. A total of 54 substance-using homeless youth (18-25 years) participated in focus groups in order to provide their perspectives on barriers to and facilitators of seeking treatment. Participants were recruited from shelters in Hollywood...

InGaN/GaN multilayer quantum dot (QD) structure is a potential type of active regions for yellow-green light-emitting diodes (LEDs). The surface morphologies and crystalline quality of GaN barriers are critical to the uniformity of InGaN QD layers. While GaN barriers were grown in multi-QD layers, we used improved growth parameters by increasing the growth temperature and switching the carrier ...

During the past 8 years numerous patients have been treated by injection of radiolabeled monoclonal antibodies for both diagnosis and treatment of cancer. It has become common to refer to this approach by such terms as "antibody guided delivery" or "antibody guided targeting." In general the results, while somewhat promising, have failed to fulfill our initial expectations. It is now clear that...

the purpose of this study was identification and applying ahp method in prioritization and comparison educational barriers and sustainable development on production of edible insects as diets from the viewpoint of selected groups. it was an applied research, research method was analytical, descriptive and statistical society was four groups of specialists, livestock and poultry producers, insec...