Zusammenfassung Die vorliegende Übersicht über die Biomarkern TIMP‑2 („tissue inhibitor of metalloprokinase 2“) und IGFBP7 („insulin-like growth factor binding protein 7“) wird im Rahmen der Serie „Biomarker“ des Zentralblatts für Arbeitsmedizin, Arbeitsschutz Ergonomie publiziert. Marker eignen sich zur Abschätzung Nierenschädigung frühen Diagnostik akuten Niereninsuffizienz. Hier zeigen diese...

CREB (cAMP responsive element binding protein) protein (CBP) and adenovirus E1A-associated 300 kDa (p300) are histone acetyltransferases, which necessary for multiple cellular processes. Thus, CBP/p300 promising potential antitumor targets. To date, despite various small molecule inhibitors of bromodomain (BRD) having been reported, no specific inhibitor was approved by U.S. Food Drug Administr...

Moringa oleifera L. leaves are known to have very high protein content and contain isoflavones, inhibiting tyrosinase activity. The study was conducted test the inhibitor activity of leaf extract formulate as a skin brightening cream. Research shows that has good an can be developed results cream formulations showed cosmetology properties (pH, homogeneity, spreadibility).

the gene tp53 (also known as protein 53 or tumor protein 53), encoding transcription factor p53, is mutated or deleted in half of human cancers, demonstrating the crucial role of p53 in tumor suppression. there are reports of nearly 250 independent germ line tp53 mutations in over 100 publications. the p53 protein has the structure of a transcription factor and, is made up of several domains. t...

Wide application of programmed cell death protein 1 (PD-1) inhibitor for tumor treatment has led to increased immune-related adverse events (irAEs), particularly cutaneous irAE. In this study, we assessed the effects external washing with self-made Xiaofeng Jiedu powder on expressions serum inflammatory cytokines in patients (AEs) induced by PD-1 inhibitor. Fifty-six AEs were randomly divided i...