We have studied the complex interrelationships between platelets, Factor XIa, a1-protease inhibitor and Factor IX activation. Platelets were shown to secrete an inhibitor of Factor XMa, and to protect Factor XIa from inactivation in the presence of a1-protease inhibitor and the secreted platelet inhibitor. This protection of Factor Ma did not arise from the binding of Factor XIa to platelets, t...

pulmonary hypertension is rare but is one of the complications that occur due to hiv infection. symptoms of hiv-associated pulmonary arterial hypertension are often non-specific but the main symptom of the disease is dyspnea. in this cross-sectional study, we measured systolic pulmonary arterial pressure (spap) by echocardiographic methods among hiv-positive patients who received art. this rese...