G9a has been reported to highly express in bladder transitional cell carcinoma (TCC) and G9a inhibition significantly attenuates cell proliferation, but the underlying mechanism is not fully understood. The present study aimed at examining the potential role of autophagy in the anti-proliferation effect of G9a inhibition on TCC T24 and UMUC-3 cell lines in vitro. We found that both pharmaceutic...

Autophagy is a highly conserved cellular process in which cytoplasmic materials are internalized into an autophagosome that later fuses with lysosome for their degradation and recycling. MicroRNAs (miRNAs) integral regulators various processes including autophagy endothelial function. Accordingly, we hypothesize miRNA, miR-378-3p, essential regulator of MiR-378-3p expression was measured follow...

Brequinar sodium (BQR) is a well-studied inhibitor of the dihydroorotate dehydrogenase (DHODH) enzyme. Both DHODH and uridine-cytidine kinase 2 (UCK2) enzymes have been reported to be over-expressed in cancer cells maintain high demand for DNA RNA their proliferation. In this study, we aim further sensitize effects BQR by knocking down UCK2 activity. DLD-1 knockdown cells, no change sensitivity...

Introduction: Evidence suggests that neuronal apoptosis in neurodegenerative diseases is correlated with inflammatory reactions. The beneficial or detrimental role of apoptosis in neuroinflammation is unclear. Elucidating this question may be helpful in management of neurodegenerative diseases. Since TNF-α is able to induce apoptosis as well as increased viability of the cells by activation ...

Stress hormones have potent growth-inhibiting effects on a variety of peripheral tissues. Consistent with this general function, stress has been shown to inhibit cell proliferation and, ultimately, neurogenesis in the hippocampus. This effect appears to be common across mammalian species, life stages, and most types of stressors. Although some evidence points to a role for glucocorticoids in me...

background: endometriosis is a complex disorder in reproductive age women which consist of stromal and epithelial cells implantation outside the uterine cavity. adiponectin is a member of cytokine family with various metabolic roles and proliferation inhibition of many cancer cells. the aim of the present research was to determine adiponectin effect on human endometriotic stromal cells (escs) p...

background: osteosarcoma is a malignant tumor with high mortality but effective therapy has not yet been developed. berberine, an isoquinoline alkaloid component in several chinese herbs including huanglian, has been shown to induce growth inhibition and the apoptosis of certain cancer cells. the aim of this study was to determine the role of berberine on human osteosarcoma cell lines u2os and ...

objective(s): the janus kinase-signal transducers and activators of transcription signaling pathway (jak/stat pathway) play an important role in proliferation of breast cancer cells. previous data showed that inhibition of stat3 suppresses the growth of breast cancer cells, but the associated mechanisms are not well understood. this study aims to investigate the effect and associated mechanisms...

Abstract Diffuse Midline Gliomas (DMG) is the leading cause of brain tumor-related death in children. Currently, radiation only treatment that offers transient benefit but almost all DMG relapse due to radioresistance. Compared normal tissue, are hypo-perfused with tumor cells being exposed hypoxia, a low oxygen microenvironment serves as potent barrier effective radiotherapy. Biguanides hypogl...