Many patients have incorrect aerosol inhalation technique with metered dose inhalers (MDI). Several inhalation aids have been developed and marketed for these patients. Even those who have correct inhalation technique may benefit from these devices. We compared bronchodilator efficacy of two puffs of albuterol aerosol administered either directly from a MDI mouthpiece, or from an inhalation aid...

Dose delivery (total emitted dose, or TED) from dry powder inhalers (DPIs), pulmonary deposition, and the biological effects depend on drug formulation and device and patient characteristics. The aim of this study was to measure, in vitro, the relationship between parameters of inhalation profiles recorded from patients, the TED and fine particle mass (FPM) of Diskus and Turbuhaler inhalers. In...

Gastroesophageal acid reflux into the airways can trigger asthma attacks. Indeed, citric acid inhalation causes bronchoconstriction in guinea pigs, but the mechanism of this effect has not been fully clarified. We investigated the role of tachykinins, bradykinin, and nitric oxide (NO) on the citric acid- induced bronchoconstriction in anesthetized and artificially ventilated guinea pigs. Citric...

The ASO field is an emerging area of drug development that targets the disease source at RNA level, offering a promising alternative to therapies targeting downstream processes. SpliSense developing SPL84, inhaled for treatment CF patients carrying 3849 +10 kb C->T mutation. In order move into clinic, we performed full battery preclinical safety and toxicology studies with SPL84. vitro in silic...

We studied the dose-dependent effects of inhaled isoetharine HCl, a beta-adrenergic bronchodilator (2.5, 5.0, 10.0, and 20.0 mg), on bronchial blood flow (Qbr) in anesthetized sheep. Isoetharine resulted in a dose-dependent increase in Qbr. With a total dose of 17.5 mg, Qbr increased from baseline values of 22 +/- 3.4 (SE) to 60 +/- 16 ml/min (P < 0.001), an effect independent of changes in car...

Abstract This study focuses on the evolution of radon concentrations in tap water samples primary schools Najaf city using a RAD-7 detector. Annual effective doses children were calculated. A Geographic Information System technique was used for mapping concentrations, annual dose (AED) ingestion, and inhalation. It found that average value AED due to ingestion 0.236 ± 0.020 μSv/year, while 0.01...

STUDY OBJECTIVE To determine the protective effect of salbutamol, 100 microg, inhaled by different devices (pressurized metered-dose inhaler [pMDI; Ventolin; GlaxoWellcome; Greenford, UK], pMDI + spacer [Volumatic; GlaxoWellcome], or breath-activated pMDI [Autohaler; 3M Pharmaceuticals; St. Paul, MN]) on bronchoconstriction induced by methacholine. DESIGN Randomized, double-blind, cross-over,...

Preclinical studies with Ba 679 Br have demonstrated a significantly longer duration of action than ipratropium bromide. Following inhalation of single doses, no systemic antimuscarinic effects were noted at doses likely to be bronchodilating in man. The objective of the present pilot-study of Ba 679 Br was to establish the dose-range for its bronchodilatory activity in a small number of chroni...

It has been established that inhaled tobramycin has a positive effect on respiratory function in Pseudomonas-aeruginosa positive patients with cystic fibrosis (CF). In a previous study the authors reported that low-dose tobramycin preparations containing the preservative phenol caused significant bronchial obstruction. Recently, high-dose tobramycin preparations with and without preservatives/p...

Radon and thoron isotopes are responsible for approximately half of the average annual effective dose to humans. Although the half-life of thoron is short, it can potentially enter indoor air from adobe walls. Adobe was a traditional construction material in the Great Hungarian Plain. Its major raw materials are the alluvial sediments of the area. Here, seasonal radon and thoron activity concen...