background: familial hypertrophic cardiomyopathy (hcm) is caused by mutations in genes encoding cardiac sarcomere proteins. nowadays genetic testing of hcm plays an important role in clinical practice by contributing to the diagnosis, prognosis, and screening of high-risk individuals. the aim of this study was developing a reliable testing strategy for hcm based on linkage analysis and appropri...

There is increasing evidence that molecular detection of micrometastatic breast cancer in the axillary lymph nodes (ALN) of breast cancer patients can improve staging. Molecular analyses of samples obtained from the Minimally Invasive Molecular Staging of Breast Cancer Trial (n = 489 patients) indicate that whereas the majority of molecular markers are informative for the detection of metastati...

BACKGROUND Microsatellites or simple sequence repeats (SSRs) are highly informative molecular markers for various biological studies in plants. In spruce (Picea) and other conifers, the development of single-copy polymorphic genomic microsatellite markers is quite difficult, owing primarily to the large genome size and predominance of repetitive DNA sequences throughout the genome. We have deve...

IONS AND METHODOLOGY Computer architecture’s heavy emphasis on simulation effectively discourages the research community from exploring other useful and possibly more informative modeling techniques. The few published papers using and proposing analytic models have not stimulated significant follow-up efforts. Stories abound of such papers receiving knee-jerk negative rejections from program co...

In the field of the architectural heritage, the representation of artefacts, particularly for communication purposes, has benefited from the development of computer-based modelling techniques in fields ranging form archaeology to geography. But numerous experts in the above mentioned heritage field have come to question the readability of realistic models inside which the hypothetical nature of...

UNLABELLED PREMISE OF THE STUDY To investigate fungal species identity and diversity in mycorrhizal fungi of order Sebacinales, we developed phylogenetic markers. These new markers will enable future studies investigating species delineation and phylogenetic relationships of the fungal symbionts and facilitate investigations into evolutionary interactions among Sebacina species and their orc...