Multiple sclerosis (MS) is a progressive and autoimmune neurodegenerative disease of the central nervous system (CNS). This disease is recognized through symptoms like inflammation, demyelination and the destruction of neurological actions. Experimental allergic encephalomyelitis (EAE) is a widely accepted animal model for MS. EAE is created in animals by injecting the tissue of myelin basic...

   Multiple sclerosis (MS) is a progressive and autoimmune neurodegenerative disease of the central nervous system (CNS). This disease is recognized through symptoms like inflammation, demyelination and the destruction of neurological actions. Experimental allergic encephalomyelitis (EAE) is a widely accepted animal model for MS. EAE is created in animals by injecting the tissue of myelin basic...

background and aims. previous data have demonstrated that berberine, a barberry plant alkaloid, possesses various therapeutic properties. this study histologically evaluated the clinical efficacy of a berberine-derived topical gel on periodontal inflammation in patients requiring surgery. materials and methods. this randomized clinical trial was performed on 14 patient (11 females, 3 males) pre...

Ischemic stroke has been classified as a merely thrombotic disease, so the main goal of its treatment is the recanalization of the occluded vasculature. However, despite fast restoration of blood circulation, progressive stroke still develops in many patients, which has led to the concept of reperfusion injury.  The underlying mechanism is only partly known. Though, it is accepted now, tha...

as in iranian traditional medicine, bee venom (bv) is a promising treatment for the rheumatoid arthritis (ra) which is considered as a problematic human chronic inflammatory disease in the present time. smoking is considered to be a major risk factor in ra onset and severity. the main aim of this study is to investigate the effects of bv on cigarette smoke-induced inflammatory response in fibro...

mesenchymal stem cells can be obtained from deferent tissues like adipose tissue, umbilical cord, placenta, skin, bone marrow, etc. these cells have regulatory effects on all types of immune cells such as dendritic cell, natural killers and lymphocytes. mesenchymal stem cells induce inhibitory phenotypes of antigen presenting cells (apcs) following their activity. they also change t cells pheno...