OBJECTIVE We examined whether biomarkers of endothelial function, fibrinolysis/thrombosis and adiponectin, predict the progression from normal to pre-diabetes more strongly among women than men over 6 years of follow-up from the Western New York Health Study. RESEARCH DESIGN AND METHODS In 2002-2004, 1,455 participants from the Western New York Health Study, who were free of type 2 diabetes a...

We have recently demonstrated that human bronchial epithelial cells can synthesise and release several inflammatory mediators, including the factor regulated on activation, normal T-cell expressed and secreted (RANTES) and soluble intercellular adhesion molecule-1 (sICAM-1), which influence the activity of eosinophils, and may, therefore play a role in the aetiology of asthma. In this study we ...

We report five children with atopic eczema. The level of soluble adhesion molecules is known to correlate with disease severity. On the assumption that atopic eczema is a T-lymphocyte-mediated inflammatory disease, in this study, we aimed to determine the presence of soluble intracellular adhesion molecule (sICAM) 1 and the release of inflammatory cytokines. The patient sera were used to measur...

729 AN INFLAMMATORY STATE IS KNOWN TO EXIST IN SLEEP DISORDERS.1,2 INTERLEUKIN-6 (IL-6), FOR EXAMPLE, IS AN INFLAMMATORY CYTOKINE THAT IS elevated in sleep apnea and narcolepsy.3-5 Better sleep is associated with decreased daytime secretion of IL-6, whereas disturbed nocturnal sleep is associated with increased daytime IL-6 levels.6 Other markers of inflammation, including plasma endothelin-1 (...

INTRODUCTION Previous reports suggest that endothelial activation is an important process in sepsis pathogenesis. We investigated the association between biomarkers of endothelial cell activation and sepsis severity, organ dysfunction sequential organ failure assessment (SOFA) score, and death. METHODS This is a prospective, observational study including adult patients (age 18 years or older)...

AIM To investigate whether high vitreous levels of the soluble intercellular adhesion molecule 1 (sICAM-1) may be related to clinical risk factors of proliferative vitreoretinopathy (PVR) and whether their measurement may serve as an additional risk indicator of this complication in eyes with rhegmatogenous retinal detachment (RRD). METHODS Levels of sICAM-1 were measured by enzyme linked imm...

BACKGROUND The natural course of sarcoidosis is variable, but no single parameter has been generally accepted as a good marker for disease activity. Adhesion molecules are required for the migration of inflammatory cells; thus, they may be markers of activity in sarcoidosis. METHODS In 16 patients with active sarcoidosis and 11 with inactive disease (10 were male, 17 were female; mean age [-/...

BACKGROUND Chronic infection in cystic fibrosis (CF) and airway inflammation leads to progressive lung injury. Neutrophils are considered to be responsible for the onset and promotion of the inflammatory response within the CF lung. The relationship between infection and inflammation is complex but circulating inflammatory markers may not truly reflect the local inflammatory response in the lun...

BACKGROUND Biomarkers facilitate early detection of disease and measurement of therapeutic efficacy, both at clinical and experimental levels. Recent advances in analytics and disease models allow comprehensive screening for biomarkers in complex diseases, such as asthma, that was previously not feasible. OBJECTIVE Using murine and nonhuman primate (NHP) models of asthma, identify biomarkers ...

BACKGROUND The association of inflammatory factors and the aqueous flare value with macular edema in branch retinal vein occlusion (BRVO) patients remains unclear. The relationship between the aqueous flare value and the vitreous fluid levels of vascular endothelial growth factor (VEGF), interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, soluble intercellular adhesion molecule 1 (sICAM-1...