Macrolide antibiotics like azithromycin inhibit bacterial growth and replication by interrupting protein synthesis. But azithromycin also has immunomodulatory properties.1 In the acute phase of infl ammation, azithromycin exerts an initial neutrophil degranulation effect and enhances the oxidative response that is primed by particulate stimulus, which could facilitate its antibacterial effects....

The pholyphenolic phytoalexin resveratrol (3,4 ́,5-trihydroxystilbene) is abundant in grape skins (with higher concentration in red as compared to white wine), peanuts, the roots of the weed Polygonum cuspidatum as well as in other fruits and vegetables (Cardile et al., 2007; Csaki et al., 2008). It is produced by plants in response to stress and has a wide range of pharmacological activities. R...

healthy people, a primary infection with human cytomegalovirus (HCMV) is often mild or even asympto-matic, but may cause a mononucleosis-like syndrome with fever, arthralgia, fatigue, thrombo cyto penia, and anemia. During acute infection, HCMV infection often leads to immune dysfunction, including both immuno-suppression and autoimmune phenomena. HCMV infection results in production of autoant...

© 2017 The Author(s). Published by Taylor & Francis on behalf of the Nordic Orthopedic Federation. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (https://creativecommons.org/licenses/by-nc/3.0) DOI 10.1080/17453674.2017.1402463 Sir,—In a recent correspondence, Dr. Mjöberg questions the role of wear particles in the pathogen...

Correspondence: Rebecca Grainger Malaghan Institute of Medical Research, PO Box 7060, Wellington, New Zealand Tel +64 4 499 6914 Fax +64 4 499 6915 Email [email protected] Abstract: Ankylosing spondylitis (AS) is a chronic, progressive disease characterized by infl ammation in the spine and sacroiliac joints which causes pain, stiffness and the potential for spinal ankylosis. It is asso...

The selecting tactics for managing patients with ulcerative colitis, an individual approach is required each patient, depending on the activity and duration of disease, as well response to previous therapy.It known that gut microbiome has a profound impact pathogenesis infl ammatory bowel disease (IBD). IBD generally characterized by reduced species richness diversity, less temporal stability, ...

not eff ective for many persons with rheumatoid arthritis (RA) and other infl ammatory rheumatic diseases. At this time RA patients had a signifi cantly decreased life expectancy due to a relatively incontrolled infl ammatory activity of RA combined with an increased incidence of comorbidities and severe treatment-related side eff ects. After 5 years of disease duration, a considerable percenta...

Therapeutics and Clinical Risk Management 2007:3(5) 705–706 © 2007 Dove Medical Press Limited. All rights reserved This issue of Therapeutics and Clinical Risk Management contains interesting reviews on rheumatoid arthritis (RA), ulcerative colitis (UC) and steroid-resistant asthma all of which are distressing chronic infl ammatory conditions of unclear etiology. Rheumatoid arthritis (RA) is a ...

 To describe the stimulus for exercise-induced bronchoconstriction.  To describe the different mechanisms whereby this stimulus may act to cause the airways to narrow in asthmatics and athletes.  To describe the relevance of the stimulus and mechanism to protocols to diagnose exercise-induced bronchoconstriction.  To describe the infl ammatory mediators involved in exercise-induced bronc...

pathogenesis Rheumatoid arthritis (RA) is a chronic infl ammatory disease characterized by the activation of synovial tissue lining the joint capsule, which results in the invasion of the cartilage and bone leading to the progressive joint dysfunction [1]. Severe morbidity and structural damage of joints caused by chronic infl ammation often lead to major personal, family, and fi nancial conseq...