OBJECTIVE To assess the adequacy of reporting of non-inferiority trials alongside the consistency and utility of current recommended analyses and guidelines. DESIGN Review of randomised clinical trials that used a non-inferiority design published between January 2010 and May 2015 in medical journals that had an impact factor >10 (JAMA Internal Medicine, Archives Internal Medicine, PLOS Medici...

Recent successes of antiretroviral pre-exposure prophylaxis (PrEP) in preventing HIV infection have raised questions whether further placebo controlled trials of new HIV-prevention technologies are ethically justifiable. A trial with active agent(s) in the comparator group can be designed either as a superiority or non-inferiority trial. In a non-inferiority trial the hypothesis tested is that ...

Author note: The study was supported by a grant from the Israel Science Foundation (Grant No. 957/13). Partial data (N = 80 out of 163) with a reduced scope of analyses were reported in the proceedings of the 35th annual conference of the Cognitive Science Society (Lauterman & Ackerman, 2013). We are grateful to Meira Ben-Gad for editorial assistance. Abstract Metacognitive monitoring that acco...

objective: for decades, both theory and research have focused on the role of self-esteem and shame in constructing narcissistic traits. however, studies on the exact relationship between these two and overt and covert facets of narcissism have been equivocal.  methods: the current study is correlational. it examined these relationships among 308 iranian college students (155 males, 153 females,...

Abstract Adverse early interactions with parents deeply affect the socio-emotional development of an individual, leading to feelings inferiority and negatively influencing self-conscious emotions, such as shame. Moreover, dysfunctional parenting was found in histories people suffering from substance behavioral addictions. In this context, there is currently no agreement literature regarding rol...

Family plays an indispensable role in the care and support of rising number older people particularly developing countries like Ethiopia where system public transfer is minimal. Previous studies focus on institutionalized urban-dwelling elderly with little attention to informal paradigm rural areas. This study aims explore health-related experiences dependent who get within a family setting. A ...

The main purpose of this research is to examine the employment crisis among unemployed youth with higher education. In particular, investigates subjective experience representatives (n = 188) in situation job loss or inability find it. For purpose, uses method ranking social and psychological spheres by criterion frustration it, as well multidimensional scaling determine cognitive constructs us...

Non-inferiority trials test whether a new product is not unacceptably worse than a product already in use. This paper introduces concepts related to non-inferiority, and discusses the regulatory views of both the European Medicines Agency and the United States Food and Drug Administration.

Interprofessional Collaboration (IPC) is the provision of health services carried out by involving various professional professions and providing comprehensive services, in collaboration with patients, families, groups communities to provide quality services. This study aims analyze implementation effective communication on IPC Inpatient Installation Hasanuddin University Hospital. The type res...

In organ transplantation, placebo-controlled clinical trials are not possible for ethical reasons, and hence non-inferiority trials are used to evaluate new drugs. Patients with a transplanted kidney typically receive three to four immunosuppressant drugs to prevent organ rejection. In the described case of a non-inferiority trial for one of these immunosuppressants, the dose is changed, and an...