Detection of adverse drug reactions (ADRs) in hospitals provides an important measure of the burden of drug related morbidity on the healthcare system. Spontaneous reporting of ADRs is scare and several obstacles to such reporting have been identified formerly. This study aimed to determine the role of clinical pharmacy residents in ADR reporting within a hospital setting.Clinical pharmacy resi...

Detection of adverse drug reactions (ADRs) in hospitals provides an important measure of the burden of drug related morbidity on the healthcare system. Spontaneous reporting of ADRs is scare and several obstacles to such reporting have been identified formerly. This study aimed to determine the role of clinical pharmacy residents in ADR reporting within a hospital setting.Clinical pharmacy resi...

In 200 sulfonamide-resistant Portuguese Salmonella isolates, 152 sul1, 74 sul2, and 14 sul3 genes were detected. Class 1 integrons were always associated with sul genes, including sul3 alone in some isolates. The sul3 gene has been identified in isolates from different sources and serotypes, which also carried a class 1 integron with aadA and dfrA gene cassettes.

abstract background: primary immunodeficiency diseases (pid) are heterogeneous group of inherited disorders mainly characterized by recurrent infections leading to several times hospital admissions. the economic impact of pid is a challenging issue; therefore, this study was designed to determine the medical costs of hospitalizations in this group of patients as an indicator of the direct cost ...

In the title compound, C(6)H(6)Cl(2)N(2)O(2)S, the O atoms of the sulfonamide group lie on one side of the benzene ring and the amino group lies on the opposite side. An inter-molecular N-H⋯Cl inter-action occurs. In the crystal, adjacent mol-ecules are linked by N-H⋯O hydrogen bonds, forming a three-dimensional structure with supporting π-π stacking inter-actions [centroid-centroid distance = ...

1 Centre National de Référence des Francisella, Institut de Biologie et Pathologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France 2 Laboratoire Adaptation et Pathogénie des Microorganismes, Université Joseph Fourier – Grenoble 1, Grenoble, France 3 Laboratoire Adaptation et Pathogénie des Microorganismes, CNRS/UJF, UMR 5163, Grenoble, France *Correspondence: mmaurin@chu-grenobl...

This work demonstrates a design strategy to optimize antimicrobial peptides with an ideal balance of minimal cytotoxicity, enhanced stability, potent cell penetration and effective antimicrobial activity, which hold great promise for the treatment of intracellular microbial infections and potentially systemic anti-infective therapy.