Aim. The side effects associated with the use of indometacin are noted by about 30-60% patients, therefore, in this context problem adverse event rate reduction is still relevant today. Cryopreserved placental extract (CEP) attracted our attention as a means pathogenetic correction ulcerogenic action indomethacin. aim paper to characterize antiulcer activity cryopreserved placenta on model indo...

The objective of present study is to evaluate the antiulcer activity of ethanolic extract of flower of Azadirachta indica. The cause of ulceration in patients is mainly due to hyper secretion of gastric acid and pepsin. Plant extracts and polyherbal formulations are some of the most attractive sources of new drugs and have been shown to produce promising results in the treatment of gastric ulce...

Nitric oxide (NO) appears to play a critical role in modulating gastric mucosal defense. Administration of NO donors has been reported to protect the gastrointestinal mucosa against damage induced by several irritants. However, the possible role of NO in healing existing ulcers must be clarified further. Therefore, the present study was designed to assess the effect of modulation of NO on the h...

Annexin-1 is a glucocorticoid-inducible protein that plays an important effector role in the resolution of inflammation and has recently been shown to contribute to the resistance of the stomach to injury. Using an integrated genetic and pharmacological approach, we have tested the hypothesis that annexin-1 contributes to the healing of mucosal injury, given that such injury is accompanied by a...

The effect of different extracts of leaves and fruits of Moringa oleifera Lam. (Moringaceae) on gastric and duodenal ulcers was evaluated by using different gastric ulcer models and cysteamine-induced duodenal ulcer method. The leaf extracts (500mg=kg, p.o.) of Moringa oleifera showed gastric ulcer healing effect in acetic acid–induced chronic gastric ulcers. The acetone extract and methanol ex...

Background and objective: The red cabbage (Brassica oleracea Linn var. capitata) is a leafy green biennial plant that contains beta-carotene, vitamin C fibre. It used in cooking for its nutritional value has known anti-inflammatory activity.This study compared the antiulcerogenic activity of Aqueous Extract Brassica (AEB) capitata with Misoprostol.Materials Method: Acute gastric ulcers were ind...

Tricyclic antidepressants are particularly useful in the treatment of endogenous depression. Since the 1950s, tricyclic antidepressants (TCAs) have also been used for the treatment of gastric ulcer disease. Many TCAs have been evaluated for their antiulcer effects, but there are presently no data in the literature specifically concerning the antidepressant opipramol. This study aimed to investi...

The healing activity of gallic acid enriched ethanolic extract (GAE) of Phyllanthus emblica fruits (amla) against the indomethacin-induced gastric ulceration in mice was investigated. The activity was correlated with the ability of GAE to alter the cyclooxygenase- (COX-) dependent healing pathways. Histology of the stomach tissues revealed maximum ulceration on the 3rd day after indomethacin (1...

There is little evidence regarding role of B. malabaricum in the treatment of inflammatory bowel disease (IBD); though it is clinically employed as a constituent of a polyherbal preparation for IBD. To establish its role as a monotherapy for IBD, preliminary phytochemical screening of aqueous extract of B. malabaricum (AEBM) was undertaken. Subsequently, its protective effect in indomethacin an...