BACKGROUND Perioperative pain treatment often consist of combinations of non-opioid and opioid analgesics, 'multimodal analgesia', in which gabapentin is currently used. The aim was to document beneficial and harmful effects of perioperative gabapentin treatment. METHODS Randomized clinical trials comparing gabapentin vs. placebo or active placebo in adult surgical patients receiving gabapent...

Mobile devices are becoming more pervasive and more advanced with respect to their processing power and memory size. Relying on the personalized and trusted nature of such devices, security features can be deployed on them in order to uniquely identify a user to a service provider. In this paper, we present a strong authentication mechanism that exploits the use of mobile devices to provide a t...

This article is the first of a series providing guidance for the use of the GRADE system of rating quality of evidence and grading strength of recommendations in systematic reviews, health technology assessments, and clinical practice guidelines addressing alternative management options. The GRADE process begins with asking an explicit question, including specification of all important outcomes...

BACKGROUND Prognosis research aims to identify factors associated with the course of health conditions. It is often challenging to judge the overall quality of research evidence in systematic reviews about prognosis due to the nature of the primary studies. Standards aimed at improving the quality of primary studies on the prognosis of health conditions have been created, but these standards ar...

Since early 1980s, great progress has been made on the classification of finite group actions on the sphere. Deep but indirect connections to representation theory were discovered. The indirectness is reflected by the existence of non-linear similarities between some linearly inequivalent representations [3], via the equivariant signature operator [MR] (see also [HP??] [4]). Whitehead torsion, ...

The GRADE method (Grading of Recommendations, Assessment, Development, and Evaluation) provides a tool for rating the quality of evidence for systematic reviews and clinical guidelines. This article aims to analyse conceptually how well grounded the GRADE method is, and to suggest improvements. The eight criteria for rating the quality of evidence as proposed by GRADE are here analysed in terms...

In the peripheral arteries, a thrombus superimposed on atherosclerosis contributes to the progression of peripheral artery disease (PAD), producing intermittent claudication (IC), ischemic necrosis, and, potentially, loss of the limb. PAD with IC is often undiagnosed and, in turn, undertreated. The low percentage of diagnosis (∼30%) in this setting of PAD is of particular concern because of the...

The recipient is a stimulus-external factor that has so far hardly been investigated in hate-speech research. However, addressing this essential to understand how and why hate speech unfolds its negative effects which characteristics of the influence these effects. present study focuses on recipient. Building previous findings from explicit ratings initial successful replications such through b...

Purpose The use of high-flow oxygen via nasal cannula has become increasingly more common in various patient populations given the multiple benefits for treating respiratory distress and failure. There is emerging, though varying research on impact delivery may have adult oropharyngeal swallowing function. purpose this literature review to outline available examine study design, investigated, f...

The article intends to show the significance of Ch. Peirce’s ideas for development contemporary philosophy, find out main directions his criticism principles Cartesian and more broadly modern philosophy (where it comes from Descartes) consider positive program which he offers as an alternative Modern philosophy. Peirce starts a pragmatic semiotic approach human nature, consciousness cognition. ...