BACKGROUND For the diagnosis of thyroid disease, measurement of "free hormone" is generally accepted as an appropriate measure. However, valid assays measuring the free fraction of thyroxine (FT4) ideally must perform without bias, despite large variations in the concentrations and affinities of serum T4-binding proteins in the population. Several approaches have been taken to overcome such bia...

The review describes a number of indirect methods in nuclear astrophysics using radioactive beams: Coulomb dissociation, transfer reactions (the ANC method), breakup of loosely bound nuclei at intermediate energies, the use other spectroscopic measurements, including -decay studies and the determination of resonance parameters. The examples chosen are drawn from the experiments the author was i...

Standard methods for indirect comparisons and network meta-analysis are based on aggregate data, with the key assumption that there is no difference between the trials in the distribution of effect-modifying variables. Methods which relax this assumption are becoming increasingly common for submissions to reimbursement agencies, such as the National Institute for Health and Care Excellence (NIC...

Cost-sensitive learning has become an increasingly important area that recognizes that real world classification problems need to take the costs of misclassification and accuracy into account. Much work has been done on cost-sensitive decision tree learning, but very little has been done on cost-sensitive Bayesian networks. Although there has been significant research on Bayesian networks there...

The tests were carried out on a carbonfibre reinforced structure with a number of wires with different kind of installation. The peak value of the current impulses ranges from 20 kA up to 200 kA and the comparison shows, that a reasonable linearity exists for carbonfibre reinforced material and that the deviations are always on the save side. The verification of the linearity has been checked t...

This article was acceptedfOr publication April 5, 1996 M any persons with brain damage refuse or avoid participating in a therapeutic program. This avoidance is a major obstacle to rehabilitation (Zencius, Lane, & Wesolowski, 1991) and may be due to cognitive impairments (e.g., decreased awareness of deficits, limited insight and judgment) (Alderman 1991). To avoid participation in therapy, the...

OBJECTIVES Immune thrombocytopenia (ITP) causes increased platelet destruction and suboptimal platelet production, increasing risk of bleeding. This analysis uses a Bayesian metaregression model to indirectly compare effectiveness of the thrombopoietin mimetics romiplostim and eltrombopag for increasing platelet counts, and contrasts the results with those of non-Bayesian approaches. METHODS ...