OBJECTIVE To compare the effectiveness and cost-effectiveness of erlotinib versus gefitinib as first-line treatment of epidermal growth factor receptor-activating mutation-positive non-small-cell lung cancer patients. DESIGN. Indirect treatment comparison and a cost-effectiveness assessment. SETTING Hong Kong. PATIENTS Those having epidermal growth factor receptor-activating mutation-positi...

Cost-sensitive learning has become an increasingly important area that recognizes that real world classification problems need to take the costs of misclassification and accuracy into account. Much work has been done on cost-sensitive decision tree learning, but very little has been done on cost-sensitive Bayesian networks. Although there has been significant research on Bayesian networks there...

background pegylated interferon alfa plus ribavirin protocol is currently considered the most efficient hepatitis c treatment. however, no evidence of costs comparison among common viral genotypes has been published. objectives we aimed to assess core drivers of hepatitis c medical care costs and compare cost effectiveness of this treatment among patients infected by hepatitis c virus with geno...

BACKGROUND Smoking imposes considerably high economic costs both on the healthcare system as well as on a country as a whole. This study was aimed at systematically reviewing the currently published literature on the direct and indirect costs associated with smoking globally. METHODS A systematic review was performed on systematically searched articles from PubMed and Scopus databases publish...

OBJECTIVES This study is conducted to estimate the cost paid by the public suffering from disease possibly caused by chemical and to examine the effect on public health. METHODS Cost-benefit analysis is an important factor in analysis and decision-making and is an important policy decision tool in many countries. Cost-of-illness (COI), a kind of scale-based analysis method, estimates the pote...

in children. although its burden is considerably preventable by vaccine, routine vaccination against hib has not been defined in the national immunization program of iran. this study was performed to assess the cost-benefit and cost‑utility of running an hib vaccination program in iran. methods: based on a previous systematic review and meta‑analysis for vaccine efficacy, we estimated the avert...

conclusions chronic hepatitis c-related liver diseases impose a substantial economic burden on patients, families and the society. the current study provides useful information on cost of treatment and work loss for different disease states, which can be further used in cost-effectiveness evaluations. results the total annual cost per patient for chronic hepatitis c, cirrhosis and hepatocellula...

Recommendations in the UK suggest restricting treatment of Alzheimer's disease with cholinesterase inhibitors, on cost-effectiveness grounds, to patients with moderate cognitive decline. As the economic analyses that informed these recommendations have been the subject of debate, we sought to address the potential limitations of existing models and produce estimates of donepezil treatment cost ...

BACKGROUND The United States (US) Department of Health and Human Services and the Office of Naval Research negotiate institutional rates for payments of overhead costs associated with administration and space usage, commonly known as indirect rates. Such payments account for a large proportion of spending by the National Institutes of Health (NIH). Little has been published about differences in...