Pyrrolizidine alkaloids (PAs) are natural toxins with multiple toxicities such as hepatotoxicity, genotoxicity and carcinogenicity to the human body. As a new risk factor in agricultural products, pyrrolizidine have been widely concerned. Efficient sensitive detection technology is an important means for effective supervision of PAs products. Liquid chromatography-tandem mass spectrometry most ...

The first total synthesis of (+)-amabiline, an unsaturated pyrrolizidine alkaloid from Cynoglossum amabile, is reported. This convergent, enantioselective synthesis proceeds in 15 steps (10-step longest linear sequence) in 6.2% overall yield and features novel methodology to construct the unsaturated pyrrolizidine or (-)-supinidine core.

We report the detection, for first time in space, of a new non-functionalised hydrocarbon cycle direction TMC-1: o -C 6 H 4 (ortho-benzyne). derive column density this (5.0 ± 1.0) × 10 11 cm −2 . The abundance species is around 30 times lower than that cyclopentadiene and indene. compare benzyne with other pure hydrocarbons, cycles or chains, find it could be formed from neutral-radical reactio...

We prepared a brand new molecule in one step for the synthesis of bis-indolylindane-1,3-dione and indan-1,3-diones from the reaction of ninhydrin and 3 substituted/unsubstituted indoles using [Hbim]BF4 ionic liquid in excellent yields. The method was also used for the synthesis of novel indene-1,3(2H)-denies derivatives.

Mol. Nutr. Food Res. 2023, 67, 202200293 DOI: 10.1002/mnfr.202200293 Pyrrolizidine alkaloid N-oxide (PANO), a common plant-based food protoxin, can be reduced to pyrrolizidine (PA) by liver S9 and gut microbiota, causing toxicity carcinogenicity. In article number 2200293, Frances Widjaja co-workers used new approach methodologies predict the relative potency (REP) of PANO PA in both rats human...

The combustion of fossil fuels forms polycyclic aromatic hydrocarbons (PAHs) composed of five- and six- membered aromatic rings, such as indene (C9 H8 ), which are carcinogenic, mutagenic, and deleterious to the environment. Indene, the simplest PAH with single five- and six-membered rings, has been predicted theoretically to be formed through the reaction of benzyl radicals with acetylene. Ben...

ABSTRACT Experimental and theoretical infrared spectra, between 4000 500 cm−1 (2.5–20 μm), band strengths of two solid phases indene, amorphous, crystalline, are given for the first time. The samples were generated via vapour deposition under high vacuum conditions on a cold surface. Density functional theory was employed calculations (IR) spectra. For lack previous information, monoclinic symm...

The metabolism in vitro of pyrrolizidine alkaloids by microsomes from eight animal species was studied. The rates of pyrrole production ranged from high to low in the following order: male hamster > male rabbit > male mouse > male rat > beef steer > beef bull female rat > wether lamb > male chicken male Japanese quail. With the exception of the rabbit and chicken, there appeared to be a direct ...