Increased generation of the arachidonic metabolites J.:[B 4 and 5-HETE by human alveolar macrophages in patients with asthma: effect in vitro of nedocromil sodium. M. Damon, C. Chavis, J.P. Daures, A. Crastes de Paulet, F.B. Miche/, Ph. Godard. * INSERM U.58, 60 rue de Navacelles, •• Departement de !'Information Mcdicale, Hopi· tal l..apcyronie, *** Clinique des Maladies Respiratoires, avenue d...

Life expectancy increased by 5 years between 2000 and 2015, the fastest increase since the 1960s. Those gains reverse declines during the 1990s, when life expectancy fell in Africa because of the AIDS epidemic and in Eastern Europe following the collapse of the Soviet Union. The increase was greatest in the African Region of WHO where life expectancy increased by 9.4 years to 60 years, driven m...

The genetic basis of cellular resistance to the anticancer drug cisdiamminedichloroplatinum(II) (CP) is not well understood. In the course of identifying genes from human tumors capable of conferring resistance to CP, we tested the ability of several types of cellular and viral ras oncogene (H, K, and N) to alter the CP response of mouse cells. Using clonogenic assays, we found that NIH 3T3 fib...

Leucovorin augments the growth inhibitory effect of 5-fluoropyrimidines on neoplastic cells. The effect is paralleled by much higher levels of DNA fragmentation than in cells treated with 5-fluoropyrimidines alone at the same concentration. The lesions are induced by a mechanism independent of incorporation of the drug into DNA, in all probability due to reduced repair of DNA lesions induced in...

The measurement of interleukin (IL)-5 in sputum is problematic, with interfering factors affecting immunoassay. The authors investigated whether sputum proteases could be acting as interfering factors by studying the effect of protease inhibitors (PI) on sputum IL-5 measurement. Induced sputa from 20 subjects with asthma were divided into aliquots, processed with and without protease inhibitors...

Life expectancy increased by 5 years between 2000 and 2015, the fastest increase since the 1960s. Those gains reverse declines during the 1990s, when life expectancy fell in Africa because of the AIDS epidemic and in Eastern Europe following the collapse of the Soviet Union. The increase was greatest in the African Region of WHO where life expectancy increased by 9.4 years to 60 years, driven m...