The aim of the present study was to formulate and evaluate nystatin containing thermosensitive mucoadhesive gel for vaginal drug delivery to achieve prolonging the residence time, sustained drug release, enhancing efficacy, decreasing recurrence, and increasing patient compliance in the treatment for vaginal candidiasis. Here nystatin (1%) as a model drug. A 3 full factorial design was employed...

background: flat urothelial lesions comprise a spectrum of morphologic changes ranging from reactive atypia to carcinoma in situ (cis). urothelial dysplasia and cis are associated with the recurrence and progression of urothelial carcinoma. distinguishing cis and dysplasia from reactive atypia based on histolopathogical features alone is often difficult. using different immunohistochemical mark...

background: various frequencies of sperm aneuploidy are reported in sperms of subfertile patients compared to normal individuals. moreover, sperm dna damage is shown to be associated with male infertility. in this study, the rate of dna damage and frequencies of aneuploidy in sperms of subfertile patients was investigated. methods: semen samples were obtained from healthy normal and subfertile ...

two facile and low cost routes were used for the synthesis of if-ws2 nanoparticles. in this paper, preparation of if-ws2 nanoparticles with two different methods was investigated. in the first method, wo3 nanoparticles were reacted with h2s gas in n2/h2 reducing atmosphere at 900 oc. the as-synthesized if-ws2 nanoparticles are spherical shape with an average size of about 70 nm.  in the second ...

in this research, using pyrolysis of phenolic resin in the presence of silicon particles, the sic ceramic composite is formed. the samples were prepared by introducing 30, 35, 40, 45 and 50 wt% of si particles to the phenolic resin. the samples were cured at 180°c then carbonized at 1100°c. the final carbonized c/si composites are hot-pressed at 1500°c in inert atmosphere, which is more than th...

a new method was used to prepare abs/pa6 blends by in situ polymerization and compatibilization method. in this process, ε-caprolactam monomer was polymerized in presence of abs via activated anionic polymerization to produce pa6. the main ingredients of the reaction mixture included: monomer ()ε-caprolactam), catalyst na-caprolactamate), microactivator hdi)( and macro-activator sma)(. then, in...

background and objective: since the advent of mammography screening, ductal carcinoma in situ (dcis) of the breast has been diagnosed increasingly. in contrast to the situation in invasive breast carcinoma, there are only a few reports on androgen receptor (ar) status in dcis and few reports on estrogen (er) and progesterone (pr) receptors. materials and methods: ar expression was examined in 5...