Multidrug resistance (MDR) continues to be a major challenge to effective chemotherapeutic interventions against cancer. Various types of cancers have been observed to exhibit this phenomenon, a strategy that involves cellular and non cellular mechanisms employed by cancer cells to survive the cytotoxic actions of various structurally and functionally unrelated drugs. The present article is a b...

The aim of this study was to determine the incidence and characteristics of pain following intracavernous injection of prostaglandin E1 (PGE). We injected PGE into the cavernous tissues of 156 patients with erectile dysfunction who had never previously been injected with PGE. The incidence and characteristics of pain after injection were evaluated by the patients' response to a questionnaire. T...

Abstract The article contains a description of a computer programme which supports diagnosis and therapy of stuttering. The application of computer technology allows for carrying out current analysis of the speech fluency disturbance level in the course of the whole therapeutic procedure. The main features of the process are: identification, classification, record of non-fluent fragments in the...

In the therapy of the hearing impaired one of the key problems is how to deal with the lack of proper auditive feedback which impedes the development of intelligible speech. The effectiveness of the therapy relies heavily on accurate phoneme recognition [?,?,?]. Because of the environmental difficulties, simple recognition algorithms may have a weak classification performance, so various techni...

The article addresses the issue of concept, scope and systemic character pardon amnesty in correlation with institution extradition. It presents divergent positions doctrine regarding interpretation nature title measures possible ways recognizing status a person who has been pardoned or amnestied, at same time request for extradition applies, by international agreements regulating transactions....