Pathophysiology of Lyme disease (LD) is complicated and depends on various factors such as individual presentation of antigens, bacterial genotype, early proper diagnosis and response to treatment. Borrelia burgdorferi localised in the skin, is covered by a coat made of saliva proteins salp, presents mostly ospC and blocks the complement system by using CRAsP. Dendritic cells (DCs) act as the f...

This paper summarizes previous in-flight infections and novel conditions of spaceflight that may suppress immune function. Granulocytosis, monocytosis, and lymphopenia are routinely observed following short duration orbital flights. Subtle changes within the monocyte and T cell populations can also be noted by flow cytometric analysis. The similarity between the immunological changes observed a...

PURPOSE To analyze the risk factors associated with Nasopharyngeal Carcinoma (NPC)in patients admitted to the ENT Department at Coltea Clinical Hospital in order to assess the similarities and differences as compared to the epidemiological data internationally reported. PATIENTS AND METHODS This is a retrospective study on 178 cases that met the inclusion criteria from 2003 to 2011. RESULTS...

The generative mechanism(s) of predisposition to Ascaris infection are currently unknown. While many factors play a role in interindividual infection intensity, much focus has been placed on the host's immunological response to infection and the underlying genetics. The present review describes the research conducted that has examined various immunological parameters and genetic factors that ma...

BACKGROUND IFN-γ is presently the only soluble immunological marker used to help diagnose latent Mycobacterium tuberculosis (M.tb) infection. However, IFN-γ is not available to distinguish latent from active TB infection. Moreover, extrapulmonary tuberculosis, such as tuberculous pleurisy, cannot be properly diagnosed by IFN-γ release assay. As a result, other disease- or infection-related immu...

introduction: recurrent abortion (ra) may be a consequence of aberrant expression of immunological factors during pregnancy. although the relative importance of immunological factors in human reproduction remains controversial, substantial evidence suggests that autoantibodies contribute to reproductive failure. production of such antibodies is under the control of cytokines; and leptin, beside...

The development of autoimmune disorders requires a combination of genetic, immunological, and environmental factors. Infectious agents, such as viruses and bacteria, can trigger autoimmunity through different mechanisms, and for systemic vasculitis in particular, microbial agents have been suggested to be involved in its pathogenesis. Although the exact mechanisms have not been fully elucidated...

The etiology and the pathogenesis of multiple sclerosis are not yet known. There might be a role for genetic susceptibility, for environmental factors and for inflammatory and immunological changes. Most of the actual therapies are based on the latter two phenomena. We review here corticosteroids, interferon beta and copolymer 1 as the current drugs of choice and compare schematically the immun...

Nerve growth factors (NGF's) were purified from mouse submaxillary gland, guinea pig prostate gland, bovine seminal plasma, and venom of Naja naja atra, and their biochemical and immunological properties were compared. The NGF's from the four sources stimulated the maximal response of nerve fiber outgrowth from chick dorsal root ganglia at 10 ng/ml. Two-site enzyme immunoassay (ETA) systems for...