1. Proteolytic (substrate nitrocasein), tripeptidase (substrate glycylglycylgly-cine) and aminopeptidase (substrate leucyl-beta-naphthylamide) activities were studied in homogenates of jejunal and ileal mucosa of 7-, 10-, 14-, 21-, 35- and 60-day-old rats. 2. Proteolytic activity was practically the same in jejunum of 7-, 10-, 14- and 21-day-old rats, but after day 21 a significant increase was...

The role of the neuroendocrine environment in the pathogenesis of enteric bacterial infections is increasingly being recognized. Here we report that norepinephrine augments Escherichia coli O157:H7-induced intestinal inflammatory and secretory responses as well as bacterial adherence to intestinal mucosa in a bovine ligated ileal loop model of infection. Norepinephrine modulation of enteritis a...

The intestinal absorption of sodium taurocholate was studied in the near-term fetal and neonatal dog. Absorption rates were measured in vivo in isolated loops of fetal jejunum and ileum. Absorption was also measured in vitro in everted sacs and rings of fetal and neonatal jejunum and ileum. The maximal rates of taurocholate absorption observed after instillation of 1 micronmol taurocholate into...

An experiment was conducted to determine if including distillers dried grains with solubles (DDGS) in the diet of growing pigs reduces the incidence or severity of infection after a Lawsonia intracellularis challenge. Eighty 17-d-old weaned pigs were blocked by sex, ancestry, and BW and randomly allotted to 1 of 4 treatment groups: negative control (NC), unchallenged, corn-soy diet; positive co...

The gut is one of the body’s major immune structures, and mucosa, which contains intestinal epithelium subepithelial cells, primary site for eliciting local responses to foreign antigens. Intestinal system development in pigs a transitional period during birth weaning. This study compares morphological immunological differences small intestine neonatal weaned piglets potentially prevent infecti...

The aim of this study was to evaluate whether dietary supplementation with an innovative silage (IS) created using 60% olive mill waste, 20% grape pomace, and deproteinised feta cheese waste solids can modulate the composition intestinal microbiota in weaned (Exp. 1) finishing 2) pigs. In Exp. 1 (40 day supplementation), forty-five crossbred pigs were randomly assigned 0% (Control), 5%, or 10% ...

Nevière, R. R., M. L. Pitt-Hyde, R. D. Piper, W. J. Sibbald, and R. F. Potter. Microvascular perfusion deficits are not a prerequisite for mucosal injury in septic rats. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G933–G940, 1999.—Our major objective was to investigate whether injury to the mucosa of the small intestine occurred in a normotensive model of sepsis and whether such inju...

BACKGROUND/AIMS Several disorders of the gastrointestinal tract are associated with abnormal serotonin (5-HT) signaling or metabolism where the 5-HT3 and 5-HT4 receptors are clinically relevant. The aim was to examine the distribution of 5-HT3, 5-HT4, and 5-HT7 receptors in the normal human colon and how this is associated with receptor interacting chaperone 3, G protein coupled receptor kin-as...

Injection of poly(A)+ RNA (mRNA) isolated from rabbit intestinal mucosa into Xenopus laevis oocytes results in an increase in sodium-independent uptake of L-[3H]leucine, L-[35S]cystine, and L-[3H]arginine. This uptake activity is related to an mRNA species corresponding to the recently isolated rabbit kidney cortex cDNA clone rBAT (related to b0,+ amino acid transporter; Bertran, J., Werner, A....