Tristetraprolin (TTP) is an adenine/uridine (AU)-rich element (ARE)-binding protein that can induce degradation of mRNAs. In this study, we report that TTP suppresses the expression of interleukin-33 (IL-33), a tumor-promoting inflammatory cytokine, and thereby inhibits the progression of gastric cancer (GC). Overexpression of TTP decreased the level of IL-33, whereas knockdown of TTP increased...

Psoriasis is a chronic and recurrent dermatitis, mediated by keratinocytes and T cells. Several proinflammatory cytokines contribute to formation and maintenance of psoriatic plaque. The Th1/Th17 pathways and some of IL-1 family members were involved in psoriasis pathogenesis and could contribute to disease activity. Therefore, we sought to analyse skin transcript levels of IL17A, IL22, RORC, I...

A IL-33 é uma citocina pleiotrópica capaz de induzir ação células envolvidas na resposta imune inata e adaptativa. Sua varia acordo com o estímulo encontrado, podendo atuar como alarmina do sistema imunológico, liberadas por danificadas podem ativar que possuem receptor ST2, a exemplo basófilos, linfoides tipo 2, eosinófilos, mastócitos Tregs quando ativadas, essas osteoclastogênese meio da red...

BACKGROUND Determination of the impact of visceral obesity and epicardial adipose tissue thickness on stimulating growth factor levels during hospitalization for myocardial infarction is of potential importance for predicting outcomes and assessing the development of cardiofibrotic changes associated with maladaptive myocardial remodeling. In this study, we aimed to investigate the relationship...

Interleukin-33 (IL-33) is a novel identified chromatin-associated cytokine of IL-1 family cytokines. It signals through a heterodimer comprised of ST2L and IL-1RAcp, and plays a crucial role in many diseases. However, very little is known about the role and underlying intricate mechanisms of IL-33 in recurrent neonatal seizure (RNS). To determine whether IL-33 plays an important regulatory role...

We investigated the role of interleukin-33 (IL-33) in airway inflammation in an experimental model of an acute exacerbation of chronic asthma, which reproduces many of the features of the human disease. Systemically sensitized female BALB/c mice were challenged with a low mass concentration of aerosolized ovalbumin for 4 weeks to induce chronic asthmatic inflammation and then received a single ...

Background Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Developing countries will have >3 times prevalence developed by year 2050. Our previous studies with a Pakistani population suggested that type 2 diabetes mellitus (T2DM) strongly associated impaired cognitive functioning, and genetic pathways showed strong resemblance to known AD patterns. The present case investig...