Previous studies indicate that lumbar radicular pain following disc herniation may be associated with release of several pro-inflammatory mediators, including interleukin-1 (IL1). In the present study, we examined how genetic variability in IL1A (rs1800587 C>T), IL1B (rs1143627 T>C) and IL1RN (rs2234677 G>A) influenced the clinical outcome the first year after disc herniation. Patients (n = 258...

Disease, Mexico City, Mexico; National Institue of Respiratory Disease, Mexico City, Mexico; Clinical Immunology and Allergy, National Institute of Respiratory Disease, Distrito Federal, Mexico. Background: Aspirin exacerbated respiratory disease (AERD) is a syndrome characterized by chronic hyperplastic rhinosinusitis, nasal polyposis, asthma and aspirin sensitivity. The mechanisms by which pr...

Active smoking accounts for 90% of lung cancer deaths, but only 15% of smokers develop lung cancer. Screening for single-nucleotide polymorphisms (SNPs) in candidate pathway genes is an approach to defining high-risk subgroup. Polymorphisms have been investigated to determine whether variations in phase I and phase II metabolism, DNA repair genes and inflammatory genes predict risk of lung canc...

The periodontium undergoes age-related cellular and clinical changes, but the involved genes are not yet known. Here, we investigated age-related genetic changes in gingiva at the transcriptomic level. Genes that were differentially expressed between young and old human gingiva were identified by RNA sequencing and verified by real-time PCR. A total of 1939 mRNA transcripts showed significantly...

BACKGROUND An association has been described between mortality in children with meningococcal disease and functional polymorphisms in the interleukin-1 (IL1) cluster. We undertook a multicenter study to evaluate associations of these polymorphisms in a Central European population. PATIENTS AND METHODS The study involved 95 Middle European pediatric hospitals. We collected blood samples from, ...

PURPOSE It has been proposed that cytokine gene polymorphisms can predispose individuals to disease by enhancing inflammatory processes. Considering the relevance of interleukin-1 (IL-1) in the pathogenesis of toxoplasmic retinochoroiditis (TR), we investigated whether IL1A -889 C/T and IL1B +3954C/T promoter polymorphisms are associated with TR in humans. METHODS We performed a cross-section...

The cold inducible RNA binding protein (CIRBP) responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. CIRBP can bind the 3'untranslated region of specific transcripts to stabilize them and facilitate their transport to ribosomes for translation. Here we used RNA interference and oligonucleotide micr...

conclusions the present study suggests a beneficial effect of vitamin c adsministration on post-transplant function of the liver from bd liver donors. results no significant differences were observed in mrna expression ratio of il1b and il10 between two groups. despite an acceptable decrease in serum concentration of the inflammatory markers il1b and il10 at time point 2 minus time point 1 (t2-...

Abstract In this study, we performed RNA sequencing of Prx II +/+ and ?/? dermal mesenchymal stem cells (DMSCs) to identify differentially expressed genes (DEGs). To explore the role in DMSCs, Gene Ontology analysis DEGs. The results showed that DEGs were mainly involved biological processes cell migration, intercellular adhesion, coordination regulation homing. Through construction protein–pro...