نتایج جستجو برای: ii deficiency

تعداد نتایج: 709333  

Journal: :Frontiers in plant science 2015
Carlos Lucena Francisco J. Romera María J. García Esteban Alcántara Rafael Pérez-Vicente

Iron (Fe) is very abundant in most soils but its availability for plants is low, especially in calcareous soils. Plants have been divided into Strategy I and Strategy II species to acquire Fe from soils. Strategy I species apply a reduction-based uptake system which includes all higher plants except the Poaceae. Strategy II species apply a chelation-based uptake system which includes the Poacea...

Journal: :Neurologia 2014
E Morales González I Contreras J A Estrada

INTRODUCTION Many studies have demonstrated that iron deficiency modifies the normal function of the central nervous system and alters cognitive abilities. When cellular damage occurs in the central nervous system, neuroprotective mechanisms, such as the production of neurotrophic factors, are essential in order for nervous tissue to function correctly. Insulin-like growth factor II (IGF- II) i...

2012
Charlotte L Alston James E Davison Francesca Meloni Francois H van der Westhuizen Langping He Hue-Tran Hornig-Do Andrew C Peet Paul Gissen Paola Goffrini Ileana Ferrero Evangeline Wassmer Robert McFarland Robert W Taylor

BACKGROUND Isolated complex II deficiency is a rare form of mitochondrial disease, accounting for approximately 2% of all respiratory chain deficiency diagnoses. The succinate dehydrogenase (SDH) genes (SDHA, SDHB, SDHC and SDHD) are autosomally-encoded and transcribe the conjugated heterotetramers of complex II via the action of two known assembly factors (SDHAF1 and SDHAF2). Only a handful of...

Journal: :Hypertension 2013
Yunfeng Xia Mark L Entman Yanlin Wang

Recent evidence indicates that inflammation plays a critical role in the initiation and progression of hypertensive kidney disease. However, the signaling mechanisms underlying the induction of inflammation are poorly understood. We found that chemokine (C-X-C motif) ligand 16 (CXCL16) was induced in renal tubular epithelial cells in response to angiotensin II in a nuclear factor-κB-dependent m...

2013
Hirokazu Kashiwagi Yoshiaki Tomiyama Shigenori Honda Satoru Kosugi Masamichi Shiraga Nobuo Nagao Sadayoshi Sekiguchi Yoshio Kanayama Yoshiyuki Kurata Yuji Matsuzawa

CD36 deficiency is divided into two subgroups: neither platelets nor monocytes express CD36 (type I deficiency), and monocytes express CD36 in spite of the lack of platelet CD36 (type II deficiency). We have already demonstrated that a 478C--T substitution (proline90serine) in platelet CD36 cDNA predominates in type II deficiency (Kashiwagi, H., S. Honda, Y. Tomiyama, H. Mizutani, H. Take, Y. H...

2017
Shintaro Sagami Yoshitaka Ueno Shinji Tanaka Akira Fujita Hiroaki Niitsu Ryohei Hayashi Hideyuki Hyogo Takao Hinoi Yasuhiko Kitadai Kazuaki Chayama

Serum levels of choline and its derivatives are lower in patients with inflammatory bowel disease (IBD) than in healthy individuals. However, the effect of choline deficiency on the severity of colitis has not been investigated. In the present study, we investigated the role of choline deficiency in dextran sulfate sodium (DSS)-induced colitis in mice. Methionine-choline-deficient (MCD) diet lo...

2013
Daisy Rymen Romain Peanne María B. Millón Valérie Race Luisa Sturiale Domenico Garozzo Philippa Mills Peter Clayton Carla G. Asteggiano Dulce Quelhas Ali Cansu Esmeralda Martins Marie-Cécile Nassogne Miguel Gonçalves-Rocha Haluk Topaloglu Jaak Jaeken François Foulquier Gert Matthijs

Congenital disorders of glycosylation (CDG) are a group of rare metabolic diseases, due to impaired protein and lipid glycosylation. In the present study, exome sequencing was used to identify MAN1B1 as the culprit gene in an unsolved CDG-II patient. Subsequently, 6 additional cases with MAN1B1-CDG were found. All individuals presented slight facial dysmorphism, psychomotor retardation and trun...

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