BACKGROUND Multiple vascular risk factors may confer very high risk, but the degree of commonality between risk factors is unclear, particularly among ethnic minorities. Furthermore, it is unknown what impact this commonality will have on the UK-based NHS Health Check Programme; a vascular disease prevention programme that screens individuals aged 40-74 years. We estimated the joint prevalence ...

OBJECTIVE Recent work has shown that insulin stimulates its own secretion in insulin-sensitive humans, suggesting that insulin resistance in the β-cell could cause β-cell dysfunction. We have tested whether insulin exposure and insulin sensitivity modulate β-cell function in subjects with normal glucose tolerance (NGT) and whether they contribute to dysglycemia in impaired glucose regulation (I...

This study aims to compare 25-hydroxy vitamin D3 (25(OH)D3), adiponectin (ADPN) and apolipoprotein A5 (apoA5) levels among subjects with different glucose tolerance and to explore their correlation with lipid metabolism. Subjects were divided into 98 cases of type 2 diabetes mellitus (T2DM group), 87 cases of impaired glucose regulation (IGR group) and 100 cases of normal glucose tolerance (NGT...

Let G be an abelian group with identity e. R a graded multiplicative hyperring and ? : Igr(R) expansion function of Igr(R), where is the set all hyperideals R. In this paper, we introduce study concepts ?-primary 2-absorbing which are extended classes prime 2- absorbing R, respectively. Moreover, give basic properties these new types investigate relations among structures.

Gene expression of nonsegmented negative-sense RNA viruses involves sequential synthesis of monocistronic mRNAs and transcriptional attenuation at gene borders resulting in a transcript gradient. To address the role of the heterogeneous rabies virus (RV) intergenic regions (IGRs) in transcription attenuation, we constructed bicistronic model RNAs in which two reporter genes are separated by the...

Inactivation of p53 has been implicated in many types of tumors particularly in non-small cell lung carcinoma, one of the most common cancers in which p53 mutation has been frequently identified. The aim of this study was to investigate the influence of p53 status on the regulation of tumor susceptibility to specific CTL-mediated cell death. For this purpose, we used a cytotoxic T lymphocyte cl...

OBJECTIVE To report the age- and sex-specific prevalences of diabetes and impaired glucose regulation (IGR) according to the revised 1999 World Health Organization criteria for diabetes in Europe. RESEARCH DESIGN AND METHODS A total of 13 studies from nine European countries with 7,680 men and 9,251 women aged 30-89 years were included in the data analysis. RESULTS In most of the study popu...

The authors aimed to determine whether 2 functional polymorphisms in the heme oxygenase-1 (HO-1) gene promoter are associated with type 2 diabetes mellitus (T2DM). A Chinese case-control study involving 1,103 newly diagnosed T2DM patients, 371 patients with impaired glucose regulation (IGR), and 1,615 controls was performed (December 2004-December 2007). A (GT)(n) microsatellite polymorphism an...

OBJECTIVE To investigate effects of glucose excursion on the oxidative/antioxidative system in subjects with different types of glucose regulation. METHODS A total of 30 individuals with normal glucose regulation (NGR), 27 subjects with impaired glucose regulation (IGR) and 27 subjects with newly diagnosed type 2 diabetes mellitus (T2DM) were selected and recruited for 3 days' continuous gluc...