Abstract Background Usual interstitial pneumonia (UIP) is a fatal disease that associated with poor prognosis and survival. Several growth factors such as IGFs (insulin-like factors) IGFBPs factor binding proteins) seem to take part this pathogenesis. Pirfenidone an immunosuppressant drug thought have anti-inflammatory anti-fibrotic effects both in vitro vivo. Objective To assess IGFBP1 IGFBP2 ...

Insulin-like growth factor (IGF) 1 and its binding proteins foster cellular proliferation and inhibit apoptosis. In vitro studies show that IGF1 increases ovarian cell growth and invasive potential, suggesting a role for the IGF1 pathway in ovarian cancer etiology. We evaluated genetic variation in the IGF1, IGFBP1 and IGFBP3 genes in relation to ovarian cancer risk by genotyping 29 haplotype-t...

Abstract Study question Does relaxin (RLX) regulate decidualization and pro- antiangiogenic factors in primary human endometrial stromal cells (hESC), decidual (pD) hTERT-immortalized hESC (T hESC)? Summary answer RLX treatment enhances affects the mRNA expression levels of factors. What is known already Patients undergoing frozen embryo transfer an artificial cycle (AC-FET) are at a 2-fold inc...

Reproduction traits play an important role in economically viable piglet production and are closely related to the quality and length of the productive life of the sow. A increased removal rate of young sows is undesirable not only because of the associated financial penalties incurred, but also because of ethical concerns. Candidate genes and gene pathways have been identified for fertility in...