نتایج جستجو برای: ifn γ
تعداد نتایج: 98732 فیلتر نتایج به سال:
OBJECTIVES To study the role of IFN-γ in the pathogenesis of systemic JIA (sJIA) and haemophagocytic lymphohistiocytosis (HLH) by searching for an IFN-γ profile, and to assess its relationship with other cytokines. METHODS Patients with inactive (n = 10) and active sJIA (n = 10), HLH [n = 5; of which 3 had sJIA-associated macrophage activation syndrome (MAS)] and healthy controls (n = 16) wer...
زمینه و هدف: نوع، شدت و مدت ورزش، تعیین کننده میزان تأثیر ورزش بر روی سیستم ایمنی است. این مطالعه با هدف تعیین اثر تمرینات با شدت های مختلف بر پاسخ الگوی سایتوکاینی در فوتبالیست های مرد دانشگاهی انجام شد. روش بررسی : در این مطالعه نیمه تجربی، 11 مرد فوتبالیست دانشگاه جهرم (میانگین قد 04/0±70/1 متر، وزن 44/6±42/64 کیلوگرم، سن 87/0±90/21 سال و شاخص توده بدنی 68/1±05/22 کیلوگرم بر مجذور متر) با حد...
INTRODUCTION Expression of Suppressor of cytokine signaling (SOCS)-1 molecules is increased in patients with tuberculosis (TB). Early Secreted Antigen Target (ESAT)-6 kDa - induced IFN-γ responses indicate Mycobacterium tuberculosis infection. The effect of ESAT6- stimulation on SOCS1 in the host is not known. METHODOLOGY Healthy asymptomatic controls had a negative (n = 16) or a positive ( n...
Background & Objective: In human malaria, genotype of cytokines affect immune system. The impact of genotype -137G/C in IL-18 and +874A/T in IFN-γ on the severity of malaria and the quality of treatment – as factors to form asymptomatic persons in endemic regions- has been investigated.Materials & Methods: 100 patients and 102 healthy persons were evaluated by Nested-PCR and thick blood fil...
چکیده سابقه و هدف: آلاینده ها منجر به کاهش سیستم دفاعی بدن در برابر عوامل عفونی می شوند. کاهش یاافزایش در سیتوکین های tnf-α، il-2 و ifn-γ در پاسخ های ایمنی به آلاینده های هوا تاثیر دارند. با توجه به اثرات متناقض آلاینده های هوا در سیستم ایمنی، هدف از این مطالعه نقش تاثیر دود ماشین بر میزان فاکتور های ایمنی همچون tnf-α، il-2 و ifn-γ در سرم رت هااست. روش بررسی: تحقیق به روش تجربی صورت گرفت و تعدا...
The present study focused on establishing the effects of interferon-gamma (IFN-γ) on interleukin-18 (IL-18) expression patterns and pregnancy outcomes in pregnant rats. Pregnant rats at the post-implantation stage were randomized into control, low IFN-γ (L-IFN-γ) and high IFN-γ groups (H-IFN-γ) that received normal saline, 100 IU/g of IFN-γ and 500 IU/g of IFN-γ vaginal muscular injection, resp...
Interferon-γ (IFN-γ) production by natural killer (NK) cells and cytotoxic lymphocytes is a key component of innate and adaptive immune responses. Because inhibitor of κB-ζ (IκBζ), a Toll-like receptor (TLR)/interleukin-1 receptor (IL-1R) inducible transcription factor, regulates IFN-γ production in KG-1 cells, we tested IκBζ's role in the classic lymphocyte pathway of IL-12/IL-18-induced IFN-γ...
Progressing cancers lose their differentiation, and acquire multiple genomic aberrations treatment resistance, what can be enhanced by tumor necrosis factor (TNF). Yet, T cell-based cancer immune therapies, require interferon (IFN)-γ TNF producing type I cells, to induce regression stable remission from metastatic disease. We therefore analyzed the effect of IFN-γ cells on phenotypic cell in en...
The cytokine interferon gamma (IFN-γ) and doxorubicin mono-therapy has been approved by the Food Drug Administration (FDA) for treatment of tumors. importance IFN-γ in immune system lies its immunomodulatory effects, antitumor therapy inhibiting RNA DNA synthesis. In this work, role activity combination with was investigated. Meanwhile, used as a vehicle to load over immunotherapy chemotherapy ...
background: malassezia furfur is alipophilic yeast that causes skin disease. objective: to evaluate the level of il-10, ifn-γ and il-12p70 in co-incubation of m. furfur grown on different forms of natural oils with pbmcs of healthy individuals. methods: pbmcs were obtained from blood samples of normal volunteers. m. furfur was cultured in different culture media containing almond oil, fish oil,...
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