Abstract Objective: Interferon-γ (IFN-γ) is a key cytokine regulating the development of atherosclerosis, but little known regarding phenotype and regulation T cells producing IFN-γ in plaques. Methods: To identify characterize IFN-γ-producing we utilized IFN-γ-YFP Nur77-GFP reporter mice crossed onto an atherosclerotic background (Apoe−/−IFN-γ YFP/YFP; Apoe−/−Nur77GFP/wt), adoptive transfer tr...

Alveolar macrophages (AMs) are not only important immune cell of the host, but also target a variety respiratory pathogens. They play an role in defense against pathogen invasion and maintaining tissue balance. Interferon (IFN)-γ is well known multipotent cytokine that has antiviral antibacterial activity enhances antigen presentation. To better reveal biological processes porcine AMs activated...

BackgroundAcute respiratory viral infections are a major cause of morbidity and mortality, especially in patients with preexisting lung diseases such as asthma. Toll-like receptors critical the early detection viruses activating innate immunity mucosa, but there is no reliable convenient method by which mucosal immune responses can be measured.ObjectiveWe sought to assess vivo an stimulus compa...

it is now well documented that interferon gamma (ifn-γ) is the indispensable cytokine for inducing protective immunity against experimental and human cutaneous leishmaniaisis. the importance of ifn-γ receptor (ifn-γr) has also been studied. in the present study, we made attempts to find out whether l. major infection is able to alter the expression of ifn-γr in vivo. in addition, we studied the...

h. pylori  is a human pathogen that colonizes the epithelium of the stomach. the host immune response may influence the disease process, where cytokines play important roles in the development of disease. in this study, the concentrations of selected cytokines in the gastric antrum and stomach body mucosa and also in the serum were evaluated. eighty patients according to their rapid urease test...

background: cell mediated immunity, especially cytotoxic t cell responses against hiv-1 infection, plays a critical role in controlling viral replication and disease progres-sion. dna vaccine is a novel technology which is known to stimulate strong cellular immune responses. many dna vaccines have been tested for hiv infection but there is still no effective vaccine against this infection. cons...

the study of cytokines gene expression is quite important in various conditions of health and disease for the evaluation of clinical responses to new vaccination approaches. an absolute quantification is based on a calibration curve and production of standard controls to achieve more reliable results than in relative system. in this study we attempted to construct standard controls to evaluate ...

Background: The interferon (IFN) pathway is a complex system with multiple proteins and diverse downstream effects on gene protein expression. IFNs have been implicated in RMDs. Despite significant potential, IFN assays not progressed into clinical practice. Objectives: To perform SLR RMDs propose consensus terminology. Methods: OvidMedline, Embase Web of Science were searched for reports up to...