The metabolic activation of a drug to an electrophilic reactive metabolite and its covalent binding to cellular macromolecules is considered to be involved in the occurrence of idiosyncratic drug toxicity (IDT). As a cellular defense system against oxidative and electrophilic stress, phase II enzymes are known to be induced through a Kelch-like ECH-associated protein 1/nuclear factor E2-related...

BACKGROUND Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food. CASE REPORT We report on a Caucasian patient experiencing recurrent severe allergic reactions to several drugs. An extensive diagnostic workup including skin prick tests, intradermal tests (IDT) and a double-blind oral challenge was performed to...

Polymer coated gas-phase sensors using the classical Rayleigh-type surface acoustic wave (RSAW) mode showed higher sensitivity and larger dynamic range compared to bulk acoustic wave (BAW) sensors, being widely used in a variety of sensor systems for chemical and biological gas detection. Using Comsol Multiphysics software, we investigated a 2D finite element model of a Surface Acoustic Wave (S...

We present a technique to address the new challenge of activity prediction in computer vision field. In activity prediction, we infer the next human activity through “classified activities” and “activity data analysis. Moreover, the prediction should be processed in real-time to avoid dangerous or anomalous activities. The combination of space–time convolutional neural networks (ST-CNN) and imp...

Extensins are hydroxyproline-rich glycoproteins (HRGPs) found in the primary cell walls of dicots. Extensin monomers are secreted into the wall and covalently bound to each other, presumably by isodityrosine (IDT) cross-links, to form a rigid matrix. Expression of the extensin matrix is correlated with inhibition of cell elongation during normal development and with increased resistance to viru...

Since the publication of Roger’s fifth edition of Diffusion of Innovations in 2003, there is a need to investigate the recent Innovation Diffusion Theory (IDT) for Information Systems (IS) research for the purpose of finding trends. Much research has been conducted and needs to be synthesized to map a direction for future research. The methodology used in this study is meta-analysis of recent I...

progesterone hypersensitivity (ph) is a rare clinical condition that  displays hypersensitivity to  endogenous  or  exogenous progesterone.  it  is characterized by cyclic dermatologic manifestations at the end of the luteal phase that disappear some days after menses. we present  a  case of  24-year-old woman  showing severe angioedema attacks occurring from the first day of her menstruation a...