The effect of intermittent calorie restriction (ICR) on cancer is controversial. In this study, we examined the effects of ICR and food content in syngeneic BALB/c mice injected with CT26 mouse colon cancer cells. Mice were subjected to 24-h fasting once a week for 4 weeks, and then provided with a control, high-calorie, or trans fatty acid-rich diet. While ICR resulted in increases in tumor we...

The formation and persistence of methylated purines was determined in mice that received a single s.c. injection of 1,2-[14C]dimethylhydrazine (15 mg/kg) and were allowed to survive for 12 or 60 hr. In mice with a low susceptibility to dimethylhydrazine-induced colon carcinogenesis (C57BL/Ha), concentrations of 7-methylguanine and O6-methylguanine in DNA of colon, ileum, and kidney were 40 to 6...

With the increase in bone metabolic diseases owing to aging of global population, interest functional food ingredients for improving health is increasing. This study aimed determine anti-osteoporosis effect Benincasa hispida extract (BHE, HR1901-W) and 2-furoic acid ovariectomy (OVX)-induced osteoporosis female ICR mice. Thirty-five mice underwent OVX or sham operation were randomized into seve...

The SAMP1/Sku mouse is a substrain of the SAMP1 (senescence-accelerated-mouse prone 1) which exhibits renal mononuclear cell infiltration from a younger age. We hypothesized that this renal characteristic is related to the incidence of tubulointerstitial nephritis (TIN). The purpose of the present study was to evaluate the applicability of the SAMP1/Sku mouse as a murine model for TIN. TIN was ...

The genetic basis for natural resistance to lethal infection with Rickettsia akari was studied in over 25 inbred strains, inbred hybrids, and outbred stocks of mice. Inbred mice infected intraperitoneally with the Kaplan strain of R. akari demonstrated three levels of response, susceptible (C3H/HeJ), intermediate (A/HeJ, A/J, A/WySn, BALB/cDub, BALB/cJ, and SJL/J), and resistant (AKR/J, AL/N, B...

The properties of multiply charged anions are dominated by intramolecular Coulomb repulsion (ICR). Using photoelectron imaging, we show the effect of ICR on photoelectron angular distributions for a series of dianions, -O2C(CH2)_{n}CO_{2};{-} (D_{n};{2-}). The observed photoemission band of D_{n};{2-} was due to a perpendicular transition from the charged end group. However, photoemission inten...

The internal consistency reliability (ICR) of the 40-item University of Pennsylvania Smell Identification Test (UPSIT) and its 10-, 20-, and 30-item fractions was explored, as well as the relationships between the fractions and the entire 40-item test. Pearson correlation coefficients (rs) were computed among all independent combinations and permutations of the four 10-item UPSIT booklets using...

An increasing number of articles in professional and scienti"c journals, as well as in the public press, give evidence to a rising number of con#icts that exist in rural communities. These con#icts arise from changes in farming practices, the increasing number of large-scale production units, resource use, and demographics. Fair, e!ective and e$cient approaches to resolve these con#icts are of ...

The ability of FT-ICR MS to resolve isotopic variants of intact proteins for each of the charge states formed by electrospray ionization offers a sensitive, rapid method for detecting "low mass" heterogeneity, where this is defined as the presence of structural variants differing in mass by 2 Da or less. Such heterogeneity may reflect biological or chemical modifications of structure or may res...