granular cell tumor is a rare benign neoplasm most commonly appears in the head and neck region, especially in the tongue, cheek mucosa, and palate. occurrence in limbs is even rarer. these tumors account for approximately 0.5% of all soft tissue tumors. granular cell tumor can also affect other organs including skin, breast, and lungs. local recurrence and metastasis is potentially higher in m...

Background: HLA-G is a nonclassical HLA class I molecule which, when elevated in tumor cells, is one of the main factors involved in tumor evasion of immune responses including NK and T cells. Objective: To evaluate the effect of HLA-G downregulation on NK cell cytotoxicity in tumor cell lines. Methods: The expression level of HLA-G was measured by real-time PCR and flowcytometry after transfec...

Congenital granular cell tumor (GCT) is a relatively rare intraoral benign tumor, approximately 200 cases of which have been reported in the neonatal period worldwide. The newborn infant may have feeding problems and respiratory difficulties due to airway obstruction. This lesion may be diagnosed by prenatal ultrasonography and simple resection is mostly required. We report a case of an adult t...

oral cavity t-cell lymphoma occurs rarely. this case report describes a patient with such a tumor. the case was a 75 years old man presented with a painless swelling on his hard palate mucosa. he had suffered from nose- bleeding and nasal obstruction. pathology revealed the presence of a t-cell lymphoma tumor in the palate. though rare, the signs and symptoms of the case suggest that t-cell lym...

  Giant Cell tumors (GCT) are benign tumors with potential for aggressive behavior and capacity to metastasize. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. Its histogenesis remains unclear. It is characterized by a proliferation of mononuclear stromal ...

Background: E-cadherin is a trans-membrane glycoprotein that plays a critical role in many aspects of cell adhesion as well as establishment and maintenance of epithelial cell polarity. Loss of the adhesive function of E-cadherin seems to promote invasive and metastatic properties of neoplastic cells. Objectives: The present study is a retrospective study aiming to evaluate the loss of E-cadher...

The malignant transformation of conventional giant cell tumor of bone (GCTOB) is rare and usually occurs with irradiation. Here we report two neglected cases of conventional GCTOB with spontaneous malignant transformation at 11 and 16 years after initial diagnosis. In the former case, the patient refused to receive any treatment following the incisional biopsy, and in the latter, the firs...

the methanolic extracts of indigofera aspalathoides (meia) and wedelia calendulaceae (mewc) were evaluated for their anticancer activity against ehrlich ascites carcinoma (eac) in swiss albino mice. on day 1, the extract of indigofera aspalathoides at a dose of 250 and 500 mg/kg body weight and the extract of wedelia calendulaceae at a dose of 250 and 500 mg/kg body weight were administered ora...