Trifluoromethyl ketones (TFK) are potent inhibitors of a variety of serine hydrolases. The TFK inhibitor, 3-(4-mercaptobutylthio)-1,1,1-trifluoro-2-propanone (MBTFP), was found to competitively inhibit cutinase activity (I50 = 9.4 x 10(-3)) from the fungal plant pathogen Monilinia fructicola and to serve as an effective affinity ligand for the purification of cutinases from culture filtrates. T...

Several commonly occurring polymorphisms in the IL-4R(alpha) have been associated with atopy in humans; the Q576R and the S503P polymorphisms reside in the cytoplasmic domain, whereas the I50 to V50 polymorphism resides in the extracellular domain of the IL-4R(alpha). The effects of these polymorphisms on signaling remain controversial. To determine the effect of the polymorphisms on IL-4 signa...

Hydroxamic acids have been reported to be potent and specific inhibitors of urease (EC 3.5.1.5) activity of plant and bacterial origin. The present investigation was performed on the inhibitory effect of hydroxamic acid derivatives of naturally occurring amino acids on the urease activity of the Jack Bean and the alimentary tracts of rats. Methionine-hydroxamic acid was the most powerful inhi...

plant dry matter accumulation has a linear relation with accumulative photosynthetically active radiation (par). intercropping could be a strategy for increasing light absorption in agronomic systems and it may improve radiation use efficiency (rue). thus this study was conducted in order to evaluate radiation absorption and use efficiency in potato (solanum tuberosum l.) –corn (zea mays l.) in...

Word Autocorrelation Redundancy Match (WARM) is an intelligent facsimile technology which compresses the image of textual documents at nominally 145:l by use of complex symbol matching on both the word and character level. At the word level, the complex symbol match rate i s enhanced by the redundancy of the word image. This creates a unique image compression capability that allows a document t...

A model is proposed for two observed current–voltage (I – V) patterns in a recent experiment with a scanning tunneling microscope tip and a carbon nanotube @Collins et al., Science 278, 100 ~1997!#. We claim that there are two mechanical contact modes for a tip ~metal!–nanotube ~semiconductor! junction ~1! with or ~2! without a tiny vacuum gap ~0.1–0.2 nm!. With the tip grounded, the tunneling ...

The Log-2 portable xenon arc light coagulator (Fig. i) was developed (O'Malley, 1971) in an attempt to simplify the operative procedure and to make this form of therapy more widely available. The key to the small size of this instrument is a parabolic reflector built into the lamp (Fig. 2). The reflector redirects the radiation so efficiently that a I50 watt lamp performs the same function as t...

Inhibition of vascular smooth muscle sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase) has been postulated as a central mechanism in enhancing vascular contractility. In the present study, kinetics of inhibition of Na-K-ATPase by lead, ouabain, and natriuretic hormone (NH) was studied in a purified hog cerebral cortex enzyme preparation. Determination of I50 values for lead, oua...