In view of the therapeutic importance of dopamine D3 and D2 receptors, there remains considerable interest in novel ligands. Herein, we show that the tetrahydroisoquinoline 1H-indole-2carboxylic acid {4-[2-(cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-cyclohexyl}-amide (SB269,652) behaves as an atypical, allosteric antagonist at D3 and D2 receptors. Accordingly, SB269,652 potently (low nanomola...

Deletion of a sequence near the fifth transmembrane domain (258RLSKV262, i3-1 mutant) and a motif residing at the proximal carboxyl tail (344KFCTR348, C-2 mutant) resulted in mu-opioid receptor mutants that were poorly expressed on the surface of transfected human embryonic kidney 293 cells. Treatment with the opioid antagonist naloxone, the agonist etorphine, and other hydrophobic ligands enha...

-----------------------------We show that the (interim) fine core of an atomless exchange economy with differential information is a subset of the ex-post core of the economy. Moreover, the interim fine core may be empty, and therefore it may be a proper subset of the ex-post core. The inclusion relation does not hold for economies with a finite number of traders.

In this paper we establish a relationship between the core cover of a compromise admissible game and the core of a particular bankruptcy game: the core cover of a compromise admissible game is, indeed, a translation of the set of coalitional stable allocations captured by an associated bankruptcy game. Moreover, we analyze the combinatorial complexity of the core cover and, consequently, of the...

A mathematical framework that permits the factorization of a joint probability distribution into its localized components for a two-dimensional array of pixels is presented. The factorization was used to estimate the contribution to mutual information of two- (I2) and three-pixel (I3) luminance correlations for a large ensemble of natural images analyzed at various spatial scales and pixel dept...

Time-resolved X-ray solution scattering is sensitive to global molecular structure and can track the dynamics of chemical reactions. In this article, we review our recent studies on triiodide ion (I3 (-)) and molecular iodine (I2) in solution. For I3 (-), we elucidated the excitation wavelength-dependent photochemistry and the solvent-dependent ground-state structure. For I2, by combining time-...

Herein, we have reported the facile synthesis of various benzimidazole / benzothiazole by using DBU-Iodine-Iodide as a green and simple catalyst. The R2NH+I3 complexes been formed reacting an aqueous mixture ammonium iodide molecular iodine with solution amine. structure has confirmed spectroscopic techniques. prepared amine-iodine screened catalyst in benzothiazoles. Among DBUH+I3complex found...