Diglycyl-L-histidine is a peptide molecule designed to mimic the specific Cu(II) transport site of human albumin. The equilibria involved in the Cu(II)-diglycyl-L-histidine system have been investigated by analytical potentiometry in aqueous solution (0.15 M NaCl, 25’). The synthetic peptide molecule bound Cu(I1) exclusively as a 1: I complex in the pH range of 6.50 to 11.00. The results furthe...

The kinetic properties of the purified pyruvate kinase (ATP: pyruvate phosphotransferase, EC 2.7.1.40) from the spore-forming bacterium Bacillus licheniformis were investigated. Catalysis by this enzyme in vitro required both monovalent and divalent cations and proceeded optimally at pH 7.0 to 7.4. The activity of purified pyruvate kinase was modulated by substrate activation (both P-enolpyruva...

A DNA segment that is highly conserved in glucokinase (hexokinase IV) and hexokinase I cDNA was used to identify specific cDNAs in a library prepared from rat adipose tissue mRNA. Some of these cDNAs were identified as being hexokinase I cDNA. Others, although similar to both the glucokinase and hexokinase I cDNAs, were unique. Two of these unique cDNAs overlapped and contained an open reading ...

Proteins with similar crystal structures can have dissimilar rates of substrate binding and catalysis. Here we used molecular dynamics simulations and biochemical analysis to determine the role of intradomain and interdomain motions in conferring distinct activation rates to two Gα proteins, Gα(i1) and GPA1. Despite high structural similarity, GPA1 can activate itself without a receptor, wherea...

Let P be a non empty poset. Observe that there exists a chain of P which is non empty. Let I1 be a relational structure. We say that I1 is chain-complete if and only if: (Def. 1) I1 is lower-bounded and for every chain L of I1 such that L is non empty holds sup L exists in I1. One can prove the following proposition (1) Let P1, P2 be non empty posets, K be a non empty chain of P1, and h be a mo...

T he seminal discovery by Mosmann and Coffman (1) that long-term CD4 + T cell clones could be segregated into subsets that produce distinct types of cytokines opened the way for extensive study of how these subsets are generated and what role they play in immune regulation as it relates to disease. Following this observation it quickly became evident in a murine model of Leishmaniasis that CD4 ...

In this study, we introduce a nonlinear leukemia dynamical system for piecewise modified ABC fractional-order derivative and analyze it the theoretical as well computational works examine crossover effect of model. For behavior operators, presume division period study [0,t2] in two subclasses I1=[0,t1], I2=[t1,t2], t1,t2∈R with t1<t2. I1, classical is considered growth while I2 fractional di...

BACKGROUND Helicobacter pylori (H. pylori)-specific genotypes have been closely correlated with an increased risk of gastric cancer (GC). The present study aimed to determine the distribution of H. pylori pathogenic genotypes amongst Iranians infected with strains representing European ancestry in areas with different GC incidence.  METHODS A total of 138 H. pylori isolates from ten districts...

The articles [25], [30], [2], [4], [3], [29], [5], [14], [27], [20], [24], [13], [1], [23], [10], [11], [8], [28], [16], [12], [21], [26], [7], [18], [19], [6], [22], [9], [15], and [17] provide the notation and terminology for this paper. In this paper n is a natural number. The following propositions are true: (1) Let G be a Go-board and i1, i2, j1, j2 be natural numbers. Suppose 1 ¬ j1 and j...