نتایج جستجو برای: i igf

تعداد نتایج: 1046035  

Journal: :American journal of physiology. Endocrinology and metabolism 2003
Mary Boes Brian L Dake Barbara A Booth Alexander Sandra Mathew Bateman Kevin L Knudtson Robert S Bar

Specific binding of IGF-binding protein (IGFBP)-3 was shown to be present in the isolated, beating rat heart. The uptake of perfused (125)I-labeled IGF-I in the beating heart was decreased to 9% by blocking IGF-I binding sites with the IGF-I analog Long R(3) (LR(3)) IGF-I. When LR(3) was perfused with complexes of (125)I-IGF-I. IGFBP-3, uptake of (125)I-IGF-I was decreased to 41%, which was sig...

Journal: :international journal of pediatrics 0
rahim vakili department of pediatrics, mashhad university of medical science, mashhad, iran. mahsa yazdan bakhsh department of pediatrics, mashhad university of medical science, mashhad, iran. mohammad vahedian department of public health, mashhad university of medical science, mashhad, iran. mahmoud mahmoudi immunology research center, mashhad university of medical science, mashhad, iran. masumeh saeidi students research committee, faculty of medicine, mashhad university of medical sciences, mashhad, iran. saba vakili students research committee, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

background: zinc is an essential trace element required for the functional activity of several enzyme systems. several studies have been carried out to assess the effect of zinc supplementation on children’s growth, but controversy exists as to the effect of zinc on growth and gh-igf-i system. objective:  the aim of this study was to evaluate the effect of zinc supplementation on linear growth ...

Journal: :American journal of physiology. Endocrinology and metabolism 2003
Jian-Wen Chen Thomas Ledet Hans Orskov Niels Jessen Sten Lund Jonathan Whittaker Pierre De Meyts Maj Britt Larsen Jens Sandahl Christiansen Jan Frystyk

At present, the circulating bioactivity of insulin-like growth factor I (IGF-I) is estimated by immunological measurements of IGF-I levels. However, immunoassays ignore the modifying effects of the IGF-binding proteins (IGFBPs) on the interaction between IGF-I and the IGF-I receptor (IGF-IR). Therefore, we developed an IGF-I kinase receptor activation assay (KIRA) based on cells transfected wit...

Journal: :Cancer research and treatment : official journal of Korean Cancer Association 2002
Seung Min Kwak Se Kyu Kim Sung Kyu Kim Chul Ho Cho

PURPOSE Insulin-like growth factor-I (IGF-I) is an important mitogen in many types of malignancies. The purpose of this study was to evaluate the role of the IGF system on cell proliferation and cell death in mouse lung cancer cell lines (3LL). MATERIALS AND METHODS Northern analysis was performed in 3LL cells. We evaluated the phosphorylation of IGF-I receptor (IGF-IR) with IGF-I stimulation...

2001
Zonghan Dai Alan D. Stiles Billie Moats-Staats

In a prior report we presented evidence that insulinlike growth factor-I (IGF-I) can act in an autocrine fashion by demonstrating that FRTL-5 cells transfected with hIGF-IA fusion genes express and secrete biologically active IGF-I that renders the stimulation of DNA synthesis in FRTL-5 cells independent of heir requirement for exogenous IGFs or insulin. To determine if IGF-1’s autocrine action...

Journal: :The Journal of clinical investigation 1986
M A De Vroede L Y Tseng P G Katsoyannis S P Nissley M M Rechler

The relative contributions of type I and type II insulinlike growth factor (IGF) receptors and IGF carrier proteins to the binding of IGF-I tracer to cultured human fibroblasts were determined in competitive binding experiments that used unlabeled insulin and synthetic insulin-IGF-I hybrid molecules containing the A chain of insulin and the B domain of IGF-I. Whereas insulin binds only to type ...

2013
Anastassios Philippou Athanasios Armakolas Michael Koutsilieris

Insulin-like growth factor-I (IGF-I) has been implicated in the pathogenesis of prostate cancer (PCa), since it plays a key role in cell proliferation, differentiation, and apoptosis. The IGF-I actions are mediated mainly via its binding to the type I IGF receptor (IGF-IR), however IGF-I signaling via insulin receptor (IR) and hybrid IGF-I/IR is also evident. Different IGF-I mRNA splice variant...

Journal: :The Biochemical journal 2007
Mehrnaz Keyhanfar Grant W Booker Jonathan Whittaker John C Wallace Briony E Forbes

The IGF-1R [type 1 IGF (insulin-like growth factor) receptor] is activated upon binding to IGF-I and IGF-II leading to cell growth, survival and migration of both normal and cancerous cells. We have characterized the binding interaction between the IGF-1R and its ligands using two high-affinity mouse anti-IGF-1R mAbs (monoclonal antibodies), 7C2 and 9E11. These mAbs both block IGF-I binding to ...

Journal: :Journal of neurochemistry 1996
H L Cheng A Randolph D Yee P Delafontaine G Tennekoon E L Feldman

The insulin-like growth factors (IGFs) are trophic factors whose growth-promoting actions are mediated via the IGF-I receptor and modulated by six IGF binding proteins (IGFBPs). In this study, we observed increased transcripts of both IGF-I and IGF-I receptor after rat sciatic nerve transection. Schwann cells (SCs) were the main source of IGF-I and IGFBP-5 immunoreactivity until 7 days after ne...

2005
K. Kita T. Shibata M. Aman Yaman K. Nagao

In order to elucidate the physiological function of circulating IGF-I on muscle protein synthesis in the chicken under malnutritional conditions, we administrated recombinant chicken IGF-I using a osmotic mini pump to fasted young chickens and measured the rate of muscle protein synthesis and plasma metabolite. The pumps delivered IGF-I at the rate of 22 μg/d {300 μg⋅(kg body weight⋅d)}. Fracti...

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